Characterisation of lung mucosal and systemic immune response in an aerosolised human BCG challenge model
Mr Shuailin Li will discuss a study that investigated the immune response induced by aerosol-inhaled, live-attenuated Mycobacterium bovis BCG in a controlled human infection model. This study used various immunological profiling techniques, including flow cytometry, single-cell RNA sequencing (scRNA-seq), and T cell receptor sequencing (TCR-seq), to examine alterations in cellular composition, gene expression, and T cell responses across lung mucosa and peripheral blood compartments. The findings provide insights into the local and systemic immune dynamics, offering a comprehensive characterization of the immunological shifts and T cell repertoires elicited by aerosolized BCG exposure.
