Publications

Publications of Interest to VALIDATE Members

Publications by VALIDATE members will be posted here (and these and further papers that may be of interest to VALIDATE members are posted on twitter)

If you have, or spot, any relevant publications for VALIDATE members, please forward them to validate@ndm.ox.ac.uk so that we can list them here.

Please could members ensure that any VALIDATE related publications include the following acknowledgement: "This work was supported by the GCRF Networks in Vaccines Research and Development VALIDATE Network, which was co-funded by the MRC and BBSRC. This UK funded award is part of the EDCTP2 programme supported by the European Union."

 

A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime – MVA85A boost in healthy UK adults Morven Wilkie, Iman Satti, Alice Minhinnick, Stephanie Harris, Michael Riste, Raquel Lopez Ramon, Sharon Sheehan, Zita-Rose Manjaly Thomas, Daniel Wright, Lisa Stockdale, Ali Hamidi, Matthew O'Shea, Kritica Dwivedi, Hannah Michaela Behrens, Tamara Davenne, Joshua Morton, Samantha Vermaak, Alison Lawrie, Paul Moss, Helen McShane. 2020 Vaccine

 

Identification of antigens presented by MHC for vaccines against tuberculosis. Paulo Bettencourt, Julius Müller, Annalisa Nicastri, Daire Cantillon, Meera Madhavan, Philip Charles, Carine Fotso, Rachel Wittenberg, Naomi Bull, Nawamin PinpathomratSimon WaddellElena Stylianou, Adrian Hill, Nicola Ternette, Helen McShane. 2020 npj Vaccines 

 

Tools for assessing the protective efficacy of TB vaccines in humans: in vitro mycobacterial growth inhibition predicts outcome of in vivo mycobacterial infection. Rachel TannerIman SattiStephanie Harris, Matthew O'Shea, Deniz Cizmeci, Daniel O'Connor, Agnieszka Chomka, Magali Matsumiya, Rachel Wittenberg, Angela Minassian, Joel Meyer, Helen Fletcher, Helen McShane. 2020 Frontiers in Immunology

 

A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. Sally Hayward, Jennifer Dowd, Helen Fletcher, Laura Nellums, Fatima Wurie, Delia Boccia. 2020 SSM - Population Health

 

Controlled human infection models - is it really feasible to give people tuberculosis? Helen McShane. 2019 American Journal of Respiratory and Critical Care Medicine

 

Final analysis of a trial of M72/ASO1E vaccine to prevent tuberculosis. Dereck Tait, Mark Hatherill, Olivier Van Der Meeren, Ann Ginsberg, Elana Van Brakel, Bruno Salaun, Thomas Scriba, Elaine Akite, Helen Ayles, Anne Bollaerts, Marie-Ange Demoitié, Andreas Diacon, Thomas Evans, Monde MuyoyetaRobert Wilkinson, et al. 2019 The New England Journal of Medicine

 

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study. Charlotte Schutz, David Barr, Bruno Andrade, Muki Shey, Amy Ward, Saskia Janssen, Rosie Burton, Katalin Wilkinson, Bianca Sossen, Kiyoshi Fukutani, Mark Nicol, Gary Maartens, Robert Wilkinson, Graeme Meintjes. 2019 PLoS Medicine

 

Emerging themes for the role of antibodies in tuberculosis. Andy Tran, Mi-Young Kim, Rajko Reljic. 2019 Immune Network

 

Insights and challenges in tuberculosis vaccine development. Helen McShane. 2019 The Lancet Respiratory Medicine

 

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial. Michele Tameris, Helen Mearns, Adam Penn-Nicholson, Yolande GreggNicole BilekSimbarashe MabweHennie Geldenhuys, Justin ShenjeAngelique LuabeyaIngrid MurilloJuana Doce, Nacho Aguilo, Dessislava Marinova, Eugenia Puentes, Esteban Rodríguez, Jesús Gonzalo-AsensioBernard FritzellJelle TholeCarlos Martin, Thomas Scriba, Mark Hatherill. 2019 The Lancet Respiratory Medicine

 

The global impact and cost-effectiveness of a melioidosis vaccine. Nantasit Luangasanatip, Stefan Flasche, David Dance, Direk Limmathurotsakul, Bart Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball, Mark Jit. 2019 BMC Medicine

 

Changes in transcript, metabolite, and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection. January Weiner, Teresa Domaszewska, Simon Donkor, Stefan Kaufmann, Philip Hill, Jayne Sutherland. 2019 Clinical Infectious Diseases

 

Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome. Fergal Duffy, January Weiner, Scott Hansen, David Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael Axthelm, Jayne Sutherland, Hazel Dockrell, Tom Ottenhoff, Thomas Scriba, Louis Picker, Gerhard Walzl, et al. 2019 Frontiers in Immunology

 

Differences in monocyte: lymphocyte ratio and tuberculosis disease progression in genetically distinct populations of macaques. Laura Sibley, Karen Gooch, Alice Wareham, Susan Gray, Andrew Chancellor, Stuart Dowall, Simon Bate, Anthony Marriott, Mike Dennis, Andrew White, Philip Marsh, Helen Fletcher, Sally Sharpe. 2019 Scientific Reports

 

The humoral immune response to BCG vaccination. Rachel Tanner, Bernardo Villarreal-Ramos, Martin Vordermeier, Helen McShane. 2019 Frontiers in Immunology

 

Survival of Mycobacterium bovis BCG oral vaccine during transit through a dynamic in vitro model simulating the upper gastrointestinal tract of badgers. Gareth Williams, Marjorie Koenen, Robert Havenaar, Paul Wheeler, Sonya Gowtage, Sandrine Lesellier, Mark Chambers. 2019 PloS ONE

 

The way forward for tuberculosis vaccines. Richard White, WillemHanekom, Johan Vekemans, Rebecca Harris. 2019 The Lancet Respiratory Medicine

 

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells. Satria A. Prabowo, Andrea ZelmerLisa Stockdale, Utkarsh Ojha, Steve SmithKarin Seifert, Helen Fletcher. 2019 Scientific Reports

 

HIV, HCMV and mycobacterial antibody levels: a cross-secontioal study in a rural Ugandan cohort. Lisa Stockdale, Stephen Nash, Angela Nalwoga, Lorna Gibson, Hannah Painter, John Raynes, Gershim Asiki, Robert Newton, Helen Fletcher. 2019 Tropical Medicine & International Health

 

Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human periphera blood mononuclear cells. Rachel Tanner, Steven Smith, Krista van Meijgaarden, Federico Giannoni, Morven Wilkie, Lucia Gabriele, Carla Palma, Hazel Dockrell, Tom Ottenhoff, Helen McShane 2019 Journal of Immunological Methods

 

Special Issue book "Global Burden and Challenges of Melioidosis". Eds Direk Limmathurotsakul, David Dance Mar 2019

 

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques. Karin Dijkman, Claudia Sombroek, Richard Vervenne, Sam Hofman, Charelle Boot, Edmond Remarque, Clemens Kocken, Tom Ottenhoff, Ivanela Kondova, Mohammed Khayum et al. 2019 Nature Medicine 

 

Dose finding for new vaccines: The role for immunostimulation/ immunodynamic modelling. Sophie Rhodes, Gwenan Knight, Denise Kirschnerb, Richard White, Thomas Evans. 2019 J Theoretical Biology

 

DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica. Elham Gholami, Fabiano Oliveira, Tahereh Taheri, Negar Seyed, Safoora Gharibzadeh, Nasim Gholami, et al. 2019 PLOS Neglected Tropical Diseases

 

 

lppz induces high cellular responsiveness in tb patients

Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection. Chen Yingying, Xiao Jia-ni, Li Yong, Xiao Yang-jiong, Xiong Yan-qing, Liu Ying, Wang Shu-jun, Ji Ping, Zhao Guo-ping, et al. 2019 Frontiers in Immunology

 

Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co‐morbidity. Nathella Kumar, Kadar Moideen, Yukthi Bhootra, Arul Nancy, Vijay Viswanathan, Basavaradhya Shruthi, Shanmugam Sivakumar, Mohan Natarajan, Hardy Kornfeld, and Subash Babu. 2018 Immunology.

 

Clinical utility of existing and second-generation interferon-γ release assays for diagnostic evaluation of tuberculosis: an observational cohort study. Hilary Whitworth, Amarjit Badhan, Aime Boakye, Yemisi Takwoingi, Melanie Rees-Roberts,Christopher Partlett, Heather Lambie, John Innes, Graham Cooke, et al. 2019 Lancet Infectious Diseases.

 
gating strategy for analysis of multifunctional t cells

Mycobacterium leprae Recombinant Antigen Induces High Expression of Multifunction T Lymphocytes and Is Promising as a Specific Vaccine for Leprosy. Márcio Bezerra-Santos, Marise do Vale-Simon, Aline Silva Barreto, Rodrigo Anselmo Cazzaniga, Daniela Teles de Oliveira, Mônica Rueda Barrios, Alex Ricardo Ferreira, Nanci Santos-Bio, Steven Reed, et al. 2018 Frontiers in Immunology

 

Next-generation Diagnostics for Melioidosis: Evaluation of a Prototype i-STAT Cartridge to Detect Burkholderia pseudomallei Biomarkers. ​​​​​​ Kevin Schully, Charles Young, Mark Mayo, Amy Connolly, Vanessa Rigas, Ammarah Spall, Alyssa Chan, Mark Salvador, James Lawler, et al. 2018 Clinical Infectious Diseases

 

Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study. Rebecca Harris, Tom Sumner, Gwenan Knight, Tom Evans, Vicky Cardenas, Chen Chen, Richard White. 2019 The Lancet Global Health

 

 

schematic representation of tyk2 dependent signaling pathways

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2missense variant. Stéphanie Boisson-Dupuis, Noe Ramirez-Alejo, Zhi Li, Etienne Patin, Geetha Rao, Gaspard Kerner, Che Kang Lim, Dimitry Krementsov, Nicholas Hernandez, et al. 2018 Science Immunology

 

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23. Rubén Martínez-Barricarte, Janet Markle, Cindy Ma, Elissa Deenick, Noé Ramírez-Alejo, Federico Mele, Daniela Latorre, Seyed Alireza Mahdaviani, Caner Aytekin et al. 2018 Science Immunology

 

Current approaches toward identifying a correlate of immune protection from tuberculosis. Iman Satti, Helen McShane. 2019 Expert Review of Vaccines

 

 sufrtb fails to grow under a low iron condition

Iron homeostasis in Mycobacterium tuberculosis is essential for persistence. Manitosh Pandey, Sakshi Talwar, Sutapa Bose, Amit Kumar Pandey. 2018 Scientific Reports

 

Burkholderia pseudomallei ΔtonB Δhcp1 Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection. Nittaya Khakhum, Preeti Bharaj, Julia Myers, Daniel Tapia, Paul Kilgore, Brittany Ross, David Walker, Janice Endsley, Alfredo Torres. 2018 mSphere

 

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. Eileen McNeill, Elena Stylianou, Mark Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley Hale, Paulo Bettencourt, Rachel Tanner, Matthew O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen Fletcher, David Greaves, Helen McShane, Keith Channon. 2018 Nature Communications

 

Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains. Jéssica da Silva Ferreira, Diego Augusto Souza, João Pedro Santos, Carla Carolina Dias Uzedo Ribeiro, Bruna Baêta, Rafaella Câmara Teixeira, Arthur da Silva Neumann, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, et al. 2018 PLOS Neglected Tropical Diseases

 

Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection. Matthew O’Shea, Thomas Fletcher, Julius Muller, Rachel Tanner, Magali Matsumiya, Jennifer Bailey, Jayne Jones, Steven Smith, Gavin Koh, William Horsnell, Nicholas Beeching, James Dunbar, Duncan Wilson , Adam Cunningham and Helen McShane. 2018 Frontiers in Immunology

 

 

Validation of a new serological assay for the identification of Mycobacterium tuberculosis complex-specific antibodies in pigs and wild boar. Jobin Thomas, Jose Infantes-Lorenzo, Inmaculada Moreno, David Cano-Terriza, Lucía de Juan, Ignacio García-Bocanegra, Lucas Domínguez, Mercedes Domínguez, Christian Gortázar, and María Risalde. 2019 Preventative Veterinary Medicine

 

Vaccine Hesitancy: Towards a Better Understanding of Drivers and Barriers to Awareness, Acceptance and Activation. Special Edition. 2018 Vaccine

 

Age-related warning of immune responses to BCG in healthy children

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries. Elizabeth Whittaker, Mark Nicol, Heather Zar, Nontobeko Tena-Coki, Beate Kampmann. 2018 Scientific Reports

 

Characterising antibody avidity in individuals of varied Mycobacterium tuberculosis infection status using surface plasmon resonance. Simon Kimuda, Irene Andia Biraro, Bernard Bagaya, John Raynes, Stephen Cose. 2018 PLOS One

 

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application. Mariateresa Coppola, Susan van den Eeden, Naoko Robbins, Louis Wilson, Kees Franken, Linda Adams, Tom Gillis, Tom Ottenhoff, Annemieke Geluk. 2018 Frontiers in Immunology

 

Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Mottram, Simon Croft, Paul Kaye. 2018 Wellcome Open Research

 

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development. Stefan Kaufmann, Hazel Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank Verreck, Ann Williams, TBVAC2020 Consortium. 2018 Frontiers in Immunology

 

Glibenclamide reduces primary human monocyte functions against tuberculosis infection

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization. Chidchamai Kewcharoenwong, Satria Prabowo, Gregory Bancroft, Helen FletcherGanjana Lertmemongkolchai. 2018 Frontiers in Immunology

 

Special Issue: Global Burden and Challenges of Melioidosis - 2018 Tropical Medicine and Infectious Disease. Including 22 Published Papers

 

Speeding Access to Vaccines and Medicines in Low- and Middle-Income Countries: A Case for Change and a Framework for Optimized Product Market Authorization. Vincent Ahonkai, Samuel Martins, Alexandre Portet, Murray Lumpkin, Dan Hartman. 2018 PLOS One

 

Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis. Olivier Van Der Meeren, Mark Hatherill, Videlis Nduba, Robert WilkinsonMonde Muyoyeta, Elana Van Brakel, Helen Ayles, German Henostroza, Friedrich Thienemann, Thomas Scriba, Andreas Diacon, Gretta Blatner, Thomas Evans, et al. 2018 New England Journal of Medicine

 

Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine, MVA85A. Anne Wajja, Milly Namutebi, Barbara Apule, Gloria Oduru, Samuel Kiwanuka, Mirriam AkelloBeatrice Nassanga, Joyce Kabagenyi, Juma Mpiima, Samantha Vermaak, Alison Lawrie, Iman Satti, Jaco Verweij, Stephen Cose, Jonathan Levin, Pontiano Kaleebu, Edridah Tukahebwa, Helen McShaneAlison Elliott. 2018 Wellcome Open Research

 

ifn y responses

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. Sophie Rhodes, Jeremie Guedj, Helen Fletcher, Thomas Lindenstrøm, Thomas Scriba, Thomas Evans, Gwenan Knight. Richard White. 2018 npj Vaccines

 

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial. Adam Penn-Nicholson, Michele Tameris, Erica Smit, Tracey Day, Munyaradzi Musvosvi, Lakshmi Jayashankar, et al. 2018 The Lancet Respiratory Medicine

 

Heterologous effects of infant BCG vaccination: potential mechanisms of immunity. Egle Butkeviciute, ChristineJones, Steven Smith. 2018 Future Microbiology

 

Leishmaniasis

Leishmaniasis. Sakib Burza, Simon Croft, Marleen Boelaert. 2018 The Lancet

 

Isolation and characterisation of alveolar type II pneumocytes from adult bovine lung. Diane Frances Lee, Francisco Javier Salguero, Duncan Grainger, Robert James Francis, Kirsty MacLellan-Gibson, Mark Andrew Chambers. 2018 Scientific Reports

 

Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4+ T cell population following BCG immunisationNaomi Bull, Daryan Kaveh, Carmen Garcia-Pelayo, Elena Stylianou, Helen McShane, Philip Hogarth. 2018 Vaccine

 

Melioidosis in Thailand: Present and FutureSoawapak Hinjoy et al (VALIDATE members: Ganjana Lertmemongkolchai, Narisara Chantratita, Apichai Taunyok, Susanna Dunachie, Surasakdi Wongratanacheewin). 2018 Trop Med Infect Dis [read other 'Melioidosis in...' papers in this Melioidosis Special Issue]

 

VALIDATE F1000 publication

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. Helen Fletcher, Mitali Chatterjee, Andrea Cooper, Tracy Hussell, Paul Kaye, Joann Prior, Rajko Reljic, Samantha Vermaak, Martin Vordermeier, Ann Williams, Helen McShane. 2018 F1000Research

 

Factors influencing the higher incidence of tuberculosis among migrants and ethnic minorities in the UK. Sally Hayward, Rosalind Harding, Helen McShane, Rachel Tanner. 2018 F1000Research

 

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention. Jennifer Dowd, Helen Fletcher, Delia Boccia. 2018 F1000Research

 

Melioidosis. W. Joost Wiersinga, Harjeet Virk, Alfredo Torres, Bart Currie, Sharon Peacock, David Dance, Direk Limmathurotsakul. 2018 Nature Reviews Disease Primers

 

Global Burden & Challenges of Melioidosis. David Dance, Direk Limmathurotsakul. 2018 Tropical Medicine and Infectious Disease

 

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines. Stephanie A Harris, Andrew White, Lisa Stockdale, Rachel Tanner, Laura Sibley, Charlotte Sarfas, Joel Meyer, Jonathan Peter, Matthew K O'Shea, Zita-Rose Manjaly Thomas, Ali Hamidi, Iman Satti, Mike J Dennis, Helen McShane, Sally Sharpe. 2018 Tuberculosis

 

 

Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis

Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. Susanna J Dunachie, Kemajittra Jenjaroen, Catherine J Reynolds, Kathryn Quigley, Ruhena Sergeant, Manutsanun Sumonwiriya, Panjaporn Chaichana, Suchintana Chumseng, Pitchayanant Ariyaprasert, Patricia Lassaux, Louise Gourlay, Charuporn Promwong, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas Day, Daniel Altmann, Rosemary Boyton. 2017 Scientific Reports. 

 

 

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