Publications

Publications of Interest to VALIDATE Members

Publications by VALIDATE members will be posted here (and these and further papers that may be of interest to VALIDATE members are posted on twitter)

If you have, or spot, any relevant publications for VALIDATE members, please forward them to validate@ndm.ox.ac.uk so that we can list them here.

Please could members ensure that any VALIDATE related publications include the following acknowledgement: "This work was supported by the GCRF Networks in Vaccines Research and Development VALIDATE Network, which was co-funded by the MRC and BBSRC. This UK funded award is part of the EDCTP2 programme supported by the European Union."

 

 

Host urine immunological biomarkers as potential candidates for the diagnosis of tuberculosis, Eribo OA et al including VALIDATE Member Gerhard Walzl, in International Journal of Infectious Disease

 

BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines, Segura-Cerda CA et al including VALIDATE Member Mario Alberto Flores-Valdez, in NPJ Vaccines

 

Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment, VALIDATE Member Mario Alberto Flores-Valdez et al, in NPJ Vaccines

 

Dual host-intracellular parasite transcriptome of enucleated cells hosting Leishmania amazonensis: control of half-life of host cell transcripts by the parasite, Orikaza C et al including VALIDATE members Hiro Goto and Eduardo Ramos Milton-Sanchez, in Infection and Immunity

 

A new Leishmania hypothetical protein can be used for accurate serodiagnosis of canine and human visceral leishmaniasis and as a potential prognostic marker for human disease, Machado AS et al including VALIDATE Member Eduardo Coelho, in Experimental Parasitology

 

Liposomal Formulation of ChimeraT, a Multiple T-Cell Epitope-Containing Recombinant Protein, Is a Candidate Vaccine for Human Visceral Leishmaniasis, Lag DP et al including VALIDATE Members Vivian Tamietti MartinsEduardo Coelho and Myron Christodoulides, in MDPI

 

Identification of gene fusion events in Mycobacterium tuberculosis that encode chimeric proteins,  VALIDATE Member Jomien Mouton et al, in NAR Genomics and Bioinformatics

 

Genetic screening for the protective antigenic targets of BCG vaccination, Smith A et Al including VALIDATE Members Bernardo Villarreal-RamosJohnjoe Mcfadden and Martin Vordermeier, in Tuberculosis

 

The potential impact of human visceral leishmaniasis vaccines on population incidence, Le Rutte EA et al, including VALIDATE Member Paul Kaye, in Plos NTD

 

Mitochondrial signature in human monocytes and resistance to infection in C. elegans during fumarate-induced Innate immune trainingPérez-Hernández AC et al including VALIDATE Members Steven SmithHazel DockrellEgle Butkeviciute, and Francisco Javier Sánchez-Garcia, in Frontiers in Immunology.

 

Recent Developments in the Application of Flow Cytometry to Advance our Understanding of Mycobacterium tuberculosis Physiology and Pathogenesis, VALIDATE Member Jomien Mouton et al, in Cytometry

 

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing based vaccine for tuberculosisLevillain F et al including VALIDATE Members Ann Rawkins, Greg Bancroft and Olivier Neyrolles, in Vaccine

 

Melioidosis in Gujarat: a neglected tropical disease, VALIDATE Network Affiliate Tushar Shaw et al, in Tropical Doctor

 

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity, Lerner T et al (including VALIDATE member Robert Wilkinson), in JCI Insight

 

Design of polymeric nanocapsules for intranasal vaccination against Mycobacterium tuberculosis: influence of the polymeric shell and antigen positioning - Diego-González L et al (with VALIDATE NMB Member Rajko Reljic), in Pharmaceutics

 

The diversity putbred mouse population is an improved animal model of vaccination against tuberculosis that reflects heterogeneity of protection - Kurtz SL et al (with VALIDATE member Igor Kramnik) in mSphere

 

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise, authors include VALIDATE members Tushar Shaw and Chiranjay Mukhopadhyay, in  JIDC

 

Altered Proteome Of A Burkholderia Pseudomallei Mutant Defective in Short-Chain Dehydrogenase Affects Cell Adhesion, Biofilm Formation And Heat Stress Tolerance, by VALIDATE Member Onrapak Reamtong and Collaborators, in Peerj

 

Towards new TB vaccines in Seminars in Immunopathology, by VALIDATE Director Helen McShane and collaborators

 

Protecting the world: Celebrating 200 years of UK vaccine research British Society for Immunology

 

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.Tarancón R et al, in PLoS Pathog 2020

 

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise, authors include VALIDATE members Tushar Shaw and Chiranjay Mukhopadhyay, in  JIDC 2020

 

Development and Characterization of an Avirulent Leishmania major Strain, Jha M et al, in the Journal of Immunology, 

 

BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny, in Frontiers in Microbiology

 

Ecology of Sand Flies: (Psychodidae: Phlebotominae) Natural Infection of Pintomyia townsendi With Leishmania amazonensis in a Cutaneous Leishmaniasis Focus in Colombia, in the Journal of Medical Entymology

 

Altered Proteome Of A Burkholderia Pseudomallei Mutant Defective in Short-Chain Dehydrogenase Affects Cell Adhesion, Biofilm Formation And Heat Stress Tolerance, by VALIDATE Member Onrapak Reamtong and Collaborators, in Peerj

 

Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells, Hannah Painter, Satria A. Prabowo, Felipe Cia, Lisa StockdaleRachel Tanner, Samuel Willcocks, Rajko ReljicHelen A. FletcherAndrea Zelmer. 2020 Scientific Reports

 

Human humoral immune responses to burkholderia pseudomallei

Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, ThailandRongkard PKronsteiner B, Hantrakun V, Jenjaroen K, Sumonwiriya M, Chaichana P, Chumseng S, Chantratita N, Wuthiekanun V, Fletcher H, Teparrukkul P, Limmathurotsakul D, Day NPJ, Dunachie S. 2020 Emerging Infectious Diseases

 

Towards new TB vaccines. Benedict Brazie, Helen McShane. 2020 Seminars in Immunopathology

 

A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA-SE) in healthy adults. Duthie MS, Frevol A, Day T, Coler R, Vergara J, Rolf T, Sagawa ZK, Marie Beckmann A, Casper C, Reed SG.

 

A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime – MVA85A boost in healthy UK adults Morven Wilkie, Iman Satti, Alice Minhinnick, Stephanie Harris, Michael Riste, Raquel Lopez Ramon, Sharon Sheehan, Zita-Rose Manjaly Thomas, Daniel Wright, Lisa Stockdale, Ali Hamidi, Matthew K. O'Shea, Kritica Dwivedi, Hannah Michaela Behrens, Tamara Davenne, Joshua Morton, Samantha Vermaak, Alison Lawrie, Paul Moss, Helen McShane. 2020 Vaccine

 

Peptide identification and selection of vaccine candidates

Identification of antigens presented by MHC for vaccines against tuberculosis. Paulo Bettencourt, Julius Müller, Annalisa Nicastri, Daire Cantillon, Meera Madhavan, Philip D. Charles, Carine B. Fotso, Rachel Wittenberg, Naomi C. Bull, Nawamin PinpathomratSimon J. WaddellElena Stylianou, Adrian V. S. Hill, Nicola Ternette, Helen McShane. 2020 npj Vaccines 

 

Tools for assessing the protective efficacy of TB vaccines in humans: in vitro mycobacterial growth inhibition predicts outcome of in vivo mycobacterial infection. Rachel TannerIman SattiStephanie Harris, Matthew K. O'Shea, Deniz Cizmeci, Daniel O'Connor, Agnieszka Chomka, Magali Matsumiya, Rachel Wittenberg, Angela M. Minassian, Joel Meyer, Helen A. Fletcher, Helen McShane. 2020 Frontiers in Immunology

 

Conceptual framework depicts several pathways through which social protection interventions may affect TB outcomes

A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. Sally E. Hayward, Jennifer B. Dowd, Helen A. Fletcher, Laura B. Nellums, Fatima Wurie, Delia Boccia. 2020 SSM - Population Health

 

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants. By VALIDATE members Rachel Tanner, Iman Satti, Stephanie Harris, Lisa Stockdale, Mbandi Kimbung, Helen McShane, Helen Fletcher and collaborators. 2019 JCL Insight

 

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challengesElena Stylianou, Matthew J. Paul, Rajko ReljicHelen McShane. 2019 Expert Review of Vaccines.

 

Development of a diagnostic compatible BCG vaccine against Bovine tuberculosis. Chandran A, Williams K, Mendum T, Stewart G, Clark S, Zadi S, McLeod N, Williams AVillarreal-Ramos BVordermeier M, Maroudam V, Prasad A, Bharti N, Banerjee R, Manjari Kasibhatla S, McFadden J. 2019 Scientific Reports

 

Controlled human infection models - is it really feasible to give people tuberculosis? Helen McShane. 2019 American Journal of Respiratory and Critical Care Medicine

 

Final analysis of a trial of M72/ASO1E vaccine to prevent tuberculosis. Dereck R. Tait, Mark Hatherill, Olivier Van Der Meeren, Ann M. Ginsberg, Elana Van Brakel, Bruno Salaun, Thomas J. Scriba, Elaine J. Akite, Helen M. Ayles, Anne Bollaerts, Marie-Ange Demoitié, Andreas Diacon, Thomas G. Evans, Monde MuyoyetaRobert J. Wilkinson, et al. 2019 The New England Journal of Medicine

 

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study. Charlotte Schutz, David Barr, Bruno B. Andrade, Muki Shey, Amy Ward, Saskia Janssen, Rosie Burton, Katalin A. Wilkinson, Bianca Sossen, Kiyoshi F. Fukutani, Mark Nicol, Gary Maartens, Robert J. Wilkinson, Graeme Meintjes. 2019 PLoS Medicine

 

Schematic representation of some of the proposed mechanisms of Ab action agains MTB infection

Emerging themes for the role of antibodies in tuberculosis. Andy C. Tran, Mi-Young Kim, Rajko Reljic. 2019 Immune Network

 

Insights and challenges in tuberculosis vaccine development. Helen McShane. 2019 The Lancet Respiratory Medicine

 

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial. Michele Tameris, Helen Mearns, Adam Penn-Nicholson, Yolande GreggNicole BilekSimbarashe MabweHennie Geldenhuys, Justin ShenjeAngelique LuabeyaIngrid MurilloJuana Doce, Nacho Aguilo, Dessislava Marinova, Eugenia Puentes, Esteban Rodríguez, Jesús Gonzalo-AsensioBernard FritzellJelle TholeCarlos Martin, Thomas J. Scriba, Mark Hatherill. 2019 The Lancet Respiratory Medicine

 

The global impact and cost-effectiveness of a melioidosis vaccine. Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball, Mark Jit. 2019 BMC Medicine

 

Changes in transcript, metabolite, and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection. January Weiner, Teresa Domaszewska, Simon Donkor, Stefan H. E. Kaufmann, Philip C. Hill, Jayne S. Sutherland. 2019 Clinical Infectious Diseases

 

Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome. Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Daniel E. Zak and The GC6-74 Consortium. 2019 Frontiers in Immunology

 

Comparison of genetically distinct populations of macaques in terms of control of TB disease

Differences in monocyte: lymphocyte ratio and tuberculosis disease progression in genetically distinct populations of macaques. Laura Sibley, Karen Gooch, Alice Wareham, Susan Gray, Andrew Chancellor, Stuart Dowall, Simon Bate, Anthony Marriott, Mike J. Dennis, Andrew D. White, Philip D. Marsh, Helen A. Fletcher, Sally Sharpe. 2019 Scientific Reports

 

The humoral immune response to BCG vaccination. Rachel Tanner, Bernardo Villarreal-Ramos, Martin Vordermeier, Helen McShane. 2019 Frontiers in Immunology

 

Survival of Mycobacterium bovis BCG oral vaccine during transit through a dynamic in vitro model simulating the upper gastrointestinal tract of badgers. Gareth A. Williams, Marjorie E. Koenen, Robert Havenaar, Paul Wheeler, Sonya Gowtage, Sandrine Lesellier, Mark A. Chambers. 2019 PloS ONE

 

The way forward for tuberculosis vaccines. Richard G. White, Willem A. Hanekom, Johan Vekemans, Rebecca C. Harris. 2019 The Lancet Respiratory Medicine

 

Immune response and growth inhibition following historical BCG vaccination

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells. Satria A. Prabowo, Andrea ZelmerLisa Stockdale, Utkarsh Ojha, Steven G. SmithKarin Seifert, Helen A. Fletcher. 2019 Scientific Reports

 

HIV, HCMV and mycobacterial antibody levels: a cross-secontioal study in a rural Ugandan cohort. Lisa Stockdale, Stephen Nash, Angela Nalwoga, Lorna Gibson, Hannah Painter, John G. Raynes, Gershim Asiki, Robert Newton, Helen A. Fletcher. 2019 Tropical Medicine & International Health

 

Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human periphera blood mononuclear cells. Rachel Tanner, Steven G. Smith, Krista E. van Meijgaarden, Federico Giannoni, Morven Wilkie, Lucia Gabriele, Carla Palma, Hazel M. Dockrell, Tom H. M. Ottenhoff, Helen McShane 2019 Journal of Immunological Methods

 

Study design diagram and monitoring of TB infecvtion by IFNy release after repeated ultra-low dose expose to M.tb

Special Issue book "Global Burden and Challenges of Melioidosis". Eds Direk Limmathurotsakul, David A. B. Dance Mar 2019

 

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques. Karin Dijkman, Claudia C. Sombroek, Richard A. W. Vervenne, Sam O. Hofman, Charelle Boot, Edmond J. Remarque, Clemens H. M. Kocken, Tom H. M. Ottenhoff, Ivanela Kondova, Mohammed A. Khayum et al. 2019 Nature Medicine 

 

Dose finding for new vaccines: The role for immunostimulation/ immunodynamic modelling. Sophie J. Rhodes, Gwenan M. Knight, Denise E. Kirschnerb, Richard G. White, Thomas G. Evans. 2019 J Theoretical Biology

 

DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica. Elham Gholami, Fabiano Oliveira, Tahereh Taheri, Negar Seyed, Safoora Gharibzadeh, Nasim Gholami, et al. 2019 PLOS Neglected Tropical Diseases

 

 

lppz induces high cellular responsiveness in tb patients

Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection. Chen Yingying, Xiao Jia-ni, Li Yong, Xiao Yang-jiong, Xiong Yan-qing, Liu Ying, Wang Shu-jun, Ji Ping, Zhao Guo-ping, et al. 2019 Frontiers in Immunology

 

Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co‐morbidity. Nathella P. Kumar, Kadar Moideen, Yukthi Bhootra, Arul Nancy, Vijay Viswanathan, Basavaradhya S.  Shruthi, Shanmugam Sivakumar, Mohan Natarajan, Hardy Kornfeld, and Subash Babu. 2018 Immunology.

 

Clinical utility of existing and second-generation interferon-γ release assays for diagnostic evaluation of tuberculosis: an observational cohort study. Hilary S. Whitworth, Amarjit Badhan, Aime A. Boakye, Yemisi Takwoingi, Melanie Rees-Roberts,Christopher Partlett, Heather Lambie, John Innes, Graham Cooke, et al. 2019 Lancet Infectious Diseases.

 
gating strategy for analysis of multifunctional t cells

Mycobacterium leprae Recombinant Antigen Induces High Expression of Multifunction T Lymphocytes and Is Promising as a Specific Vaccine for Leprosy. Márcio Bezerra-Santos, Marise do Vale-Simon, Aline Silva Barreto, Rodrigo Anselmo Cazzaniga, Daniela Teles de Oliveira, Mônica Rueda Barrios, Alex Ricardo Ferreira, Nanci Santos-Bio, Steven G. Reed, et al. 2018 Frontiers in Immunology

 

Next-generation Diagnostics for Melioidosis: Evaluation of a Prototype i-STAT Cartridge to Detect Burkholderia pseudomallei Biomarkers. ​​​​​​ Kevin L. Schully, Charles C. Young, Mark Mayo, Amy L. Connolly, Vanessa Rigas, Ammarah Spall, Alyssa A. Chan, Mark G. Salvador, James V. Lawler, et al. 2018 Clinical Infectious Diseases

 

Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study. Rebecca C. Harris, Tom Sumner, Gwenan M. Knight, Thomas G. Evans, Vicky Cardenas, Chen Chen, Richard G. White. 2019 The Lancet Global Health

 

schematic representation of tyk2 dependent signaling pathways

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2missense variant. Stéphanie Boisson-Dupuis, Noe Ramirez-Alejo, Zhi Li, Etienne Patin, Geetha Rao, Gaspard Kerner, Che Kang Lim, Dimitry N. Krementsov, Nicholas Hernandez, et al. 2018 Science Immunology

 

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23. Rubén Martínez-Barricarte, Janet Markle, Cindy Ma, Elissa Deenick, Noé Ramírez-Alejo, Federico Mele, Daniela Latorre, Seyed Alireza Mahdaviani, Caner Aytekin et al. 2018 Science Immunology

 

Current approaches toward identifying a correlate of immune protection from tuberculosis. Iman Satti, Helen McShane. 2019 Expert Review of Vaccines

 

 sufrtb fails to grow under a low iron condition

Iron homeostasis in Mycobacterium tuberculosis is essential for persistence. Manitosh Pandey, Sakshi Talwar, Sutapa Bose, Amit Kumar Pandey. 2018 Scientific Reports

 

Burkholderia pseudomallei ΔtonB Δhcp1 Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection. Nittaya Khakhum, Preeti Bharaj, Julia N. Myers, Daniel Tapia, Paul B. Kilgore, Brittany N. Ross, David H. Walker, Janice J. Endsley, Alfredo G. Torres. 2018 mSphere

 

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David Greaves, Helen McShane, Keith Channon. 2018 Nature Communications

 

Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains. Jéssica da Silva Ferreira, Diego Augusto Souza, João Pedro Santos, Carla Carolina Dias Uzedo Ribeiro, Bruna A. Baêta, Rafaella Câmara Teixeira, Arthur da Silva Neumann, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, et al. 2018 PLOS Neglected Tropical Diseases

 

Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection. Matthew K. O’Shea, Thomas E. Fletcher, Julius Muller, Rachel Tanner, Magali Matsumiya, Jennifer W. Bailey, Jayne Jones, Steven G. Smith, Gavin Koh, William G. Horsnell, Nicholas J. Beeching, James Dunbar, Duncan Wilson , Adam F. Cunningham and Helen McShane. 2018 Frontiers in Immunology

 

 

Validation of a new serological assay for the identification of Mycobacterium tuberculosis complex-specific antibodies in pigs and wild boar. Jobin Thomas, Jose A. Infantes-Lorenzo, Inmaculada Moreno, David Cano-Terriza, Lucía de Juan, Ignacio García-Bocanegra, Lucas Domínguez, Mercedes Domínguez, Christian Gortázar, and María A. Risalde. 2019 Preventative Veterinary Medicine

 

Vaccine Hesitancy: Towards a Better Understanding of Drivers and Barriers to Awareness, Acceptance and Activation. Special Edition. 2018 Vaccine

 

Age-related warning of immune responses to BCG in healthy children

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries. Elizabeth Whittaker, Mark P. Nicol, Heather J. Zar, Nontobeko G. Tena-Coki, Beate Kampmann. 2018 Scientific Reports

 

Characterising antibody avidity in individuals of varied Mycobacterium tuberculosis infection status using surface plasmon resonance. Simon G. Kimuda, Irene Andia Biraro, Bernard S. Bagaya, John G. Raynes, Stephen Cose. 2018 PLOS One

 

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application. Mariateresa Coppola, Susan J. F. van den Eeden, Naoko Robbins, Louis Wilson, Kees L. M. C. Franken, Linda B. Adams, Tom P. Gillis, Tom H. M. Ottenhoff, Annemieke Geluk. 2018 Frontiers in Immunology

 

Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Mottram, Simon L. Croft, Paul M. Kaye. 2018 Wellcome Open Research

 

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development. Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank Verreck, Ann Williams, TBVAC2020 Consortium. 2018 Frontiers in Immunology

 

Glibenclamide reduces primary human monocyte functions against tuberculosis infection

 

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 PolarizationChidchamai Kewcharoenwong, Satria A. Prabowo, Gregory Bancroft, Helen A. FletcherGanjana Lertmemongkolchai. 2018 Frontiers in Immunology

 

Special Issue: Global Burden and Challenges of Melioidosis - 2018 Tropical Medicine and Infectious Disease. Including 22 Published Papers

 

Speeding Access to Vaccines and Medicines in Low- and Middle-Income Countries: A Case for Change and a Framework for Optimized Product Market Authorization. Vincent Ahonkai, Samuel Martins, Alexandre Portet, Murray Lumpkin, Dan Hartman. 2018 PLOS One

 

Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis. Olivier Van Der Meeren, Mark Hatherill, Videlis Nduba, Robert J. WilkinsonMonde Muyoyeta, Elana Van Brakel, Helen M. Ayles, German Henostroza, Friedrich Thienemann, Thomas J. Scriba, Andreas Diacon, Gretta L. Blatner, Thomas G. Evans, et al. 2018 New England Journal of Medicine

 

Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine, MVA85A. Anne Wajja, Milly Namutebi, Barbara Apule, Gloria Oduru, Samuel Kiwanuka, Mirriam AkelloBeatrice Nassanga, Joyce Kabagenyi, Juma Mpiima, Samantha Vermaak, Alison Lawrie, Iman Satti, Jaco Verweij, Stephen Cose, Jonathan Levin, Pontiano Kaleebu, Edridah Tukahebwa, Helen McShaneAlison Elliott. 2018 Wellcome Open Research

 

ifn y responses

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. Sophie J. Rhodes, Jeremie Guedj, Helen A. Fletcher, Thomas Lindenstrøm, Thomas J. Scriba, Thomas G. Evans, Gwenan M. Knight. Richard G. White. 2018 npj Vaccines

 

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial. Adam Penn-Nicholson, Michele Tameris, Erica Smit, Tracey Day, Munyaradzi Musvosvi, Lakshmi Jayashankar, et al. 2018 The Lancet Respiratory Medicine

 

Heterologous effects of infant BCG vaccination: potential mechanisms of immunity. Egle Butkeviciute, Christine E. Jones, Steven G. Smith. 2018 Future Microbiology

 

Leishmaniasis

Leishmaniasis. Sakib Burza, Simon L. Croft, Marleen Boelaert. 2018 The Lancet

 

Isolation and characterisation of alveolar type II pneumocytes from adult bovine lung. Diane Frances LeeFrancisco Javier Salguero, Duncan Grainger, Robert James Francis, Kirsty MacLellan-Gibson, Mark A. Chambers. 2018 Scientific Reports

 

Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4+ T cell population following BCG immunisationNaomi C. Bull, Daryan A. Kaveh, Carmen Garcia-Pelayo, Elena Stylianou, Helen McShane, Philip J. Hogarth. 2018 Vaccine

 

Melioidosis in Thailand: Present and FutureSoawapak Hinjoy et al (VALIDATE members: Ganjana Lertmemongkolchai, Narisara Chantratita, Apichai Taunyok, Susanna Dunachie, Surasakdi Wongratanacheewin). 2018 Trop Med Infect Dis [read other 'Melioidosis in...' papers in this Melioidosis Special Issue]

 

VALIDATE F1000 publication

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. Helen A. Fletcher, Mitali Chatterjee, Andrea Cooper, Tracy Hussell, Paul M. Kaye, Joann Prior, Rajko Reljic, Samantha Vermaak, Martin Vordermeier, Ann Williams, Helen McShane. 2018 F1000Research

 

Factors influencing the higher incidence of tuberculosis among migrants and ethnic minorities in the UK. Sally E. Hayward, Rosalind M. Harding, Helen McShane, Rachel Tanner. 2018 F1000Research

 

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention. Jennifer B. Dowd, Helen A. Fletcher, Delia Boccia. 2018 F1000Research

 

Melioidosis. W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul. 2018 Nature Reviews Disease Primers

 

Global Burden & Challenges of Melioidosis. David A. B. Dance, Direk Limmathurotsakul. 2018 Tropical Medicine and Infectious Disease

 

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines. Stephanie A. Harris, Andrew D. White, Lisa Stockdale, Rachel Tanner, Laura Sibley, Charlotte Sarfas, Joel Meyer, Jonathan Peter, Matthew K. O'Shea, Zita-Rose Manjaly Thomas, Ali Hamidi, Iman Satti, Mike J. Dennis, Helen McShane, Sally Sharpe. 2018 Tuberculosis

 

Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis

Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. Susanna J Dunachie, Kemajittra Jenjaroen, Catherine J. Reynolds, Kathryn J. Quigley, Ruhena Sergeant, Manutsanun Sumonwiriya, Panjaporn Chaichana, Suchintana Chumseng, Pitchayanant Ariyaprasert, Patricia Lassaux, Louise Gourlay, Charuporn Promwong, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P. J. Day, Daniel M. Altmann, Rosemary J. Boyton. 2017 Scientific Reports