Dinesh Mondal

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Dinesh Mondal

Senior Scientist (Emeritus)

International Centre for Diarrhoeal Disease Research (icddr,b), Bangladesh

Email: din63d@icddrb.org

 

 

 

 

VALIDATE Role:

Network Investigator

 

Research Keywords:

NTDs, VBDs, Nutrition, Clinical trial, Diagnostics

 

Biography:

I have been working in visceral leishmaniasis (VL) research since 2006 and have now gained substantial experience in this field. During this time, I have succeeded in building well-trained teams for basic, clinical, diagnostic, vector-ecology and operational research on VL and other NTDs. Many of our novel contributions to VL research have been adopted by the National Programs of VL endemic countries such as single dose liposomal amphotericin B (AmBisome) for treatment of VL in the rural hospitals and early detection of cases with VL and PKDL by different active case detection strategies. For the first time we demonstrated that: diagnosis of VL is feasible by examining peripheral buffy coat smear; Durable Wall Lining is effective for sand fly control; a mass bed-net impregnation program with slow release insecticide tablets is effective for sand fly control and reducing VL burden; insecticidal wall paints is the most powerful tool with longer duration of efficacy for controlling sandflies compared to all existing vector control tools currently; and VL related mortality is high among tribal populations in Bangladesh. We first established that macular cases of PKDL are infectious to sand flies, therefor they must be treated to prevent outbreak of VL; insecticidal wall paints are effective for controlling sand flies; Miltefosine at allometric doses for treatment of PKDL in children and adolescents is safe and effective; PKDL development and VL relapse are related to the different treatment regimens for primary VL; urine antigen detection test for diagnosis of VL and PKDL is highly sensitive and specific; and molecular tools like qPCR and RPA are sensitive for detection of pathogens in sandflies and mosquitoes therefore are excellent tools for xenomonitoring in the post validation phases of elimination of VL and LF, and for early warning of Dengue outbreak as well. Our innovation like mobile suitcase lab for rapid detection of leishmania infection is a real breakthrough in rapid molecular diagnosis of VL and other diseases like Dengue, Malaria and Leptospirosis. All these were possible thanks to the excellent collaboration and financial support from TDR, WHO, Geneva, Switzerland, Bill and Melinda Gates Foundation, NTD, WHO, Geneva, Switzerland, IDRI, Seattle, USA, Thrasher Research Funds, USA, FIND, Geneva, Switzerland, DNDi, Geneva, Switzerland, PATH, India / USA, Liverpool School of Tropical Medicine, UK and University of Leipzig, Germany. Our vision is to develop cost-effective therapeutic and preventive strategies including vaccine against VL and other diseases of public health importance.

 

Related Websites:

ResearchGate Profile

 

Key Publications:

  • Mondal D, Bern C, Ghosh D, Rashid M, Molina R, Chowdhury R, Nath R, Ghosh P,Chapman L, Alim A, Bilbe G, Alvar J. Quantifying the infectiousness of post-kala-azar dermal leishmaniasis towards sandflies. Clin Infect Dis. 2018 Oct 24. doi: 10.1093/cid/ciy891. [Epub ahead of print] PubMed PMID: 30357373.
  • Mondal D, Ghosh P, Khan MA, Hossain F, Böhlken-Fascher S, Matlashewski G,Kroeger A, Olliaro P, Abd El Wahed A. Mobile suitcase laboratory for rapid detection of Leishmania donovani using recombinase polymerase amplification assay. Parasit Vectors. 2016 May 13;9(1):281. doi: 10.1186/s13071-016-1572-8. PubMed PMID: 27177926; PubMed Central PMCID: PMC4868004.
  • Mondal D, Das ML, Kumar V, Huda MM, Das P, Ghosh D, Priyanka J, Matlashewski G, Kroeger A, Upfill-Brown A, Chowdhury R. Efficacy, Safety and Cost of Insecticide Treated Wall Lining, Insecticide Treated Bed Nets and Indoor Wall Wash with Lime for Visceral Leishmaniasis Vector Control in the Indian Sub-continent: A Multi-country Cluster Randomized Controlled Trial. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004932. doi: 10.1371/journal.pntd.0004932. eCollection 2016 Aug. PubMed PMID: 27533097; PubMed Central PMCID: PMC4988640.
  • Mondal D, Jorge Alvar, Md. Golam Hasnain, Md. Shakhawat Hossain, Debashis Ghosh, M Mamun Huda, Shah Golam Nabi, Shyam Sundar, Greg Matlashewski, and Byron Arana. Efficacy and safety of single-dose liposomal amphotericin B for visceral leishmaniasis in a rural public hospital in Bangladesh: a feasibility study. Lancet Global Health (www.thelancet.com/lancetgh Published online December 5, 2013 http://dx.doi.org/10.1016/S2214-109X(13)70118-9)
  • Mondal D, Huda MM, Karmoker MK, Ghosh D, Matlashewski G, Nabi SG, Kroeger A. Reducing visceral leishmaniasis by insecticide impregnation of bed-nets,Bangladesh. Emerg Infect Dis. 2013 Jul;19(7):1131-4. doi: 10.3201/eid1907.120932.
  • Mondal D, Minak J, Alam M, Liu Y, Dai J, Korpe P, Liu L, Haque R, Petri WA Jr. Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clin Infect Dis. 2012 Jan 15;54(2):185-92. Epub 2011 Nov 21. PubMed PMID: 22109945; PubMed Central PMCID: PMC3245731.
  • Mondal D, Khan MG. Recent advances in post-kala-azar dermal leishmaniasis. Curr Opin Infect Dis. 2011 Oct;24(5):418-22. Review. PubMed PMID: 21885919.
  • Mondal D, Chowdhury R, Huda MM, Maheswary NP, Akther S, Petzold M, Kumar V, Das ML, Gurung CK, Ghosh D, Kroeger A. Insecticide-treated bed nets in rural Bangladesh: their potential role in the visceral leishmaniasis elimination programme. Trop Med Int Health. 2010 Nov;15(11):1382-9. doi: 10.1111/j.1365-3156.2010.02635.x.
  • Mondal D, Kamrul Nahar Nasrin, M. Mamun Huda, Mamun Kabir, Md. Shakhawat Hossain, Axel Kroeger, Tania Thomas, and Rashidul Haque. Enhanced case detection and improved diagnosis of PKDL in a kala-azar-endemic area of Bangladesh. PLoS NTD 2010 Oct 5;4(10). pii: e832
  • Mondal D, Singh SP, Kumar N, Joshi A, Sundar S, Das P, Siddhivinayak H, Kroeger A, Boelaert M. Visceral leishmaniasis elimination programme in India, Bangladesh, and Nepal: reshaping the case finding/case management strategy. PLoS Negl Trop Dis. 2009; 3(1):e355.