Warangkana Chantima

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Researcher

Mahidol University, Thailand

Email: Warangkana.chn@mahidol.ac.th

 

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords:

M. tuberculosis, Antibody Production, Infectious Disease

 

Biography:

I completed my PhD in Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University. My research project was producing mouse monoclonal antibodies that specifically target a candidate biomarker of cancer, the EpCAM protein, using the hybridoma technique. The antibodies were demonstrated that they were effective for in vivo imaging of tumor xenografts. During my postdoctoral research at Imperial College London and the University of Oxford from 2016 to 2019, I refined my experiences in producing and characterizing monoclonal antibodies. The focus of the project was on developing and characterizing human monoclonal antibodies (hmAbs) targeting the Yellow Fever virus. Subsequently, in 2020, I commenced a research position at Mahidol University, bringing a wealth of experience in generating and characterizing hmAbs to a project titled "The Dynamics of Anti-Dengue Antibodies over Time." Collaborating with our co-investigators, we successfully produced multiple anti-NS1 hmAbs derived from patients with Dengue Fever (DF) and Dengue Haemorrhagic Fever (DHF) caused by DENV serotype 1. These hmAbs have undergone thorough characterization, including evaluations of cross-reactivity and binding epitopes. At Present, our focus is on investigating humoral immune response to Mycobacterium tuberculosis.

 

Related Websites:

Mahidol University

 

Key Publications:

  • Suntronwong, N., Kanokudom, S., Auphimai, C., Thongmee, T., Assawakosri, S., Vichaiwattana, P., Yorsaeng, R., Duangchinda, T., Chantima, W., Pakchotanon, P., Nilyanimit, P., Srimuan, D., Thatsanathorn, T., Sudhinaraset, N., Wanlapakorn, N., & Poovorawan, Y. (2024). Long-Term Dynamic Changes in Hybrid Immunity over Six Months after Inactivated and Adenoviral Vector Vaccination in Individuals with Previous SARS-CoV-2 Infection. Vaccines, 12(2), 180.
  • Suntronwong, N., Kanokudom, S., Assawakosri, S., Vichaiwattana, P., Klinfueng, S., Phowatthanasathian, H., Chansaenroj, J., Srimuan, D., Thatsanathorn, T., Duangchinda, T., Chantima, W., Pakchotanon, P., Sudhinaraset, N., Wanlapakorn, N., & Poovorawan, Y. (2023). Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 134, 18–22.
  • Assawakosri, S., Kanokudom, S., Suntronwong, N., Auphimai, C., Nilyanimit, P., Vichaiwattana, P., Thongmee, T., Duangchinda, T., Chantima, W., Pakchotanon, P., Srimuan, D., Thatsanatorn, T., Klinfueng, S., Yorsaeng, R., Sudhinaraset, N., Wanlapakorn, N., Mongkolsapaya, J., Honsawek, S., & Poovorawan, Y. (2022). Neutralizing Activities Against the Omicron Variant After a Heterologous Booster in Healthy Adults Receiving Two Doses of CoronaVac Vaccination. The Journal of infectious diseases, 226(8), 1372–1381.
  • Wessel, A. W., Kose, N., Bombardi, R. G., Roy, V., Chantima, W., Mongkolsapaya, J., Edeling, M. A., Nelson, C. A., Bosch, I., Alter, G., Screaton, G. R., Fremont, D. H., Crowe, J. E., Jr, & Diamond, M. S. (2020). Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy. Nature communications, 11(1), 5278.
  • Khantasup, K., Saiviroonporn, P., Jarussophon, S., Chantima, W., & Dharakul, T. (2018). Anti-EpCAM scFv gadolinium chelate: a novel targeted MRI contrast agent for imaging of colorectal cancer. Magma (New York, N.Y.), 31(5), 633–644.
  • Chantima, W., Thepthai, C., Cheunsuchon, P., & Dharakul, T. (2017). EpCAM expression in squamous cell carcinoma of the uterine cervix detected by monoclonal antibody to the membrane-proximal part of EpCAM. BMC cancer, 17(1), 811.
  • Khantasup, K.*, Chantima, W.*, Sangma, C., Poomputsa, K., & Dharakul, T. (2015). Design and Generation of Humanized Single-chain Fv Derived from Mouse Hybridoma for Potential Targeting Application. Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(6), 404–417. (*Co-first author)
  • Treerattrakoon, K., Chantima, W., Apiwat, C. et al. Oriented conjugation of antibodies against the epithelial cell adhesion molecule on fluorescently doped silica nanoparticles for flow-cytometric determination and in vivo imaging of EpCAM, a biomarker for colorectal cancer. Microchim Acta 184, 1941–1950 (2017).