Mark Chambers

Mark Chambers

Post Doctoral Research Fellow

Africa Health Research Institute (AHRI), South Africa

Email: Mark.chambers@ahri.org

 

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords:

TB, Diagnostics, Post-TB Lung Disease

 

Biography:

My research is currently focused on the development of biomarkers of TB infection in patient sputum, focusing primarily on neutrophil proteins. The end goal being to develop a point of care test to determine likeliness of TB patients to develop post TB lung complications. I am aiming to do this through a unique combination of lung health indicators combined with proteomic data collected from South African TB patients.

 

Key Publications:

  • Detailed phenotyping reveals diverse and highly skewed neutrophil subsets in both the blood and airways during active tuberculosis infection, Nhamoyebonde, S., Chambers, M. et al(2024) – Journal: Frontiers in Immunology, DOI:10.3389/fimmu.2024.1422836
  • B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles, Krause, R. et al (2024) – Journal: Nature Communications Biology DOI:10.1038/s42003-024-06282-7
  • CD200R modulates immune control of human tuberculosis, Ahmed, M. et al (2024) – Journal: Frontiers in Immunology, DOI:10.3389/fimmu.2024.1360412