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Investigator and Coordinator of the Immunology and Cell Biology Laboratory
Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Colombia
Email: ofernandez@cideim.org.co
VALIDATE Role:
Network Associate
Research Keywords:
Pre-clinical Research - Leishmaniasis
Biography:
My research focuses on understanding host-pathogen interactions in tropical infectious diseases, particularly immune responses in leishmaniasis to develop immunotherapeutic strategies. Currently, my focus is to understand the relationship between host immune response and treatment outcomes in antimony-resistant Leishmania (Viannia) infections.
Related Websites:
CIDEIM
Key Publications:
- Fernandez OL, Belew AT, Rosales-chilama M, Sánchez- A, Colmenares M, Saravia NG, et al. Interplay of human macrophage response and natural resistance of L. ( V.) panamensis to pentavalent antimony. BioRxiv 2024.10.29.620724; doi: https://doi.org/10.1101/2024.10.29.620724.
- Fernández OL, Rosales-Chilama M, Sánchez-Hidalgo A, Gómez P, Rebellón-Sánchez DE, Regli IB, Díaz-Varela M, Tacchini-Cottier F, Saravia NG. Natural resistance to meglumine antimoniate is associated with treatment failure in cutaneous leishmaniasis caused by Leishmania (Viannia) panamensis. PLoS Negl Trop Dis. 2024 May 6;18(5):e0012156. doi: 10.1371/journal.pntd.0012156.PMID: 38709850; PMCID: PMC11098511.
- Díaz-Varela M, Sanchez-Hidalgo A, Calderon-Copete S, Tacchini V, Shipley TR, Ramírez LG, Marquis J, Fernández OL, Saravia NG, Tacchini-Cottier F. The different impact of drug-resistant Leishmania on the transcription programs activated in neutrophils. iScience. 2024 Apr 18;27(5):109773. doi: 10.1016/j.isci.2024.109773. PMID: 38711445; PMCID: PMC11070714.
- Fernández OL, Ramírez LG, Díaz-Varela M, Tacchini-Cottier F, Saravia NG. 2021. Neutrophil Activation: Influence of Antimony Tolerant and Susceptible Clinical Strains of L. (V.) panamensis and meglumine antimoniate. Front Cell Infect Microbiol. Sep 22;11:710006. doi: 10.3389/fcimb.2021.710006. PMID: 34631596 PMCID: PMC8493214.
- Navas A; Fernández O; Gallego C; Castro MM; Cossio A; Rosales M; Murillo J; Saravia NG; McMahon-Pratt D; Gómez MA. 2020. Profiles of local and systemic inflammation in the outcome of treatment of human cutaneous leishmaniasis caused by L. Viannia. Infect Immun. 88:e00764-19. https://doi.org/10.1128/IAI .00764-19. PMID: 31818959. PMCID: PMC7035935.
- Ehrlich AK; Fernandez O; Rodriguez-Pinto D; Castilho TM; Corral-Caridad MJ; Goldsmith-Pestana K; Saravia NG; McMahon-Pratt D. 2017. Local delivery of the Toll-Like Receptor 9 ligand CpG downregulates host immune and inflammatory responses; ameliorating established Leishmania (Viannia) panamensis Chronic Infection. Infect Immun. March 2017. 85(3):e00981-16. doi: 10.1128/IAI.00981-16. PMID: 28052994. PMCID: PMC5328479.
- Gonzalez-Fajardo L; Fernández O; McMahon-Pratt D; Saravia NG. 2015. Ex vivo host and parasite response to antileishmanial drugs and immunomodulators. PLoS Negl Trop Dis. 9(2):e0003621. doi: 10.1371/journal.pntd.0003621. PMID: 26024228. PMCID: PMC4449175.
- Herrera S, Fernández OL, Vera O, Cardenas W, Ramirez O, Palacios R, Chen-Mok M, Corradin G, Arévalo-Herrera M. Phase I Safety and Immunogenicity Trial of Plasmodium vivax CS Derived Long Synthetic Peptides Adjuvanted with Montanide ISA 720 or Montanide ISA 51. Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):12-20. doi: 10.4269/ajtmh.2011.09-0516.
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