Paul Klenerman

Paul Klenerman

Professor

University of Oxford, United Kingdom (UK)

Email: Paul.klenerman@ndm.ox.ac.uk

 

 

 

 

VALIDATE Role:

Network Investigator

 

Research Keywords:

T Cell Immunology/Single-Cell and Transcriptional Transcriptomic Approaches

 

Biography:

Paul Klenerman trained in medicine at Cambridge and Oxford and specialised in infectious diseases.  He has been funded mainly by the Wellcome, initially working on HIV with Andrew McMichael and Rodney Phillips, then with Rolf Zinkernagel and Hans Hengartner in Zurich on LCMV and returning to Oxford to set up studies on T cells in chronic infections such as HCV and CMV. His group have worked on vaccines, especially adenoviral vector vaccines and the types of memory induced, including memory inflation. He currently has studies looking at unconventional T cells such as MAIT cells in infectious diseases and cancer. Recent work includes studies of TB using single cell transcriptomic techniques focused on CSF analysis in meningitis in collaboration with the team at OUCRU.

 

Related Websites:

University of Oxford - Staff Profile

 

Key Publications:

  • Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, and et al., Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature, 1994. 369(6479): p. 403-7. (490 citations) 
  • Meier, U.C*., P. Klenerman, P*. Griffin, W. James, B. Koppe, B. Larder, A. McMichael, and R. Phillips, Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants. Science, 1995. 270(5240): p. 1360-2. *Joint 1st author. (135 citations)
  • Klenerman, P. and R.M. Zinkernagel, Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature, 1998. 394(6692): p. 482-5. (408 citations)
  • Klenerman, P., H. Hengartner, and R.M. Zinkernagel, A non-retroviral RNA virus persists in DNA form. Nature, 1997. 390(6657): p. 298-301.(205 citations)
  • Day, C.L., D.E. Kaufmann, P. Kiepiela, J.A. Brown, E.S. Moodley, S. Reddy, E.W. Mackey, J.D. Miller, A.J. Leslie, C. DePierres, Z. Mncube, J. Duraiswamy, B. Zhu, Q. Eichbaum, M. Altfeld, E.J. Wherry, H.M. Coovadia, P.J. Goulder, P. Klenerman, R. Ahmed, G.J. Freeman, and B.D. Walker, PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature, 2006. 443(7109): p. 350-4. (2930 citations)
  • Lechner, F., D.K. Wong, P.R. Dunbar, R. Chapman, R.T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, and B.D. Walker, Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med, 2000. 191(9): p. 1499-512. (1581 citations)
  • Lauer, G.M., E. Barnes, M. Lucas, J. Timm, K. Ouchi, A.Y. Kim, C.L. Day, G.K. Robbins, D.R. Casson, M. Reiser, G. Dusheiko, T.M. Allen, R.T. Chung, B.D. Walker, and P. Klenerman, High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology, 2004. 127(3): p. 924-36. (378 citations) 
  • Barnes, E., A. Folgori, S. Capone, L. Swadling, S. Aston, A. Kurioka, J. Meyer, R. Huddart, K. Smith, R. Townsend, A. Brown, R. Antrobus, V. Ammendola, M. Naddeo, G. O'Hara, C. Willberg, A. Harrison, F. Grazioli, M.L. Esposito, L. Siani, C. Traboni, Y. Oo, D. Adams, A. Hill, S. Colloca, A. Nicosia, R. Cortese, and P. Klenerman, Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci Transl Med, 2012. 4(115): p. 115ra1. (476 citations)
  • Karrer, U., S. Sierro, M. Wagner, A. Oxenius, H. Hengel, U.H. Koszinowski, R.E. Phillips, and P. Klenerman, Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J Immunol, 2003. 170(4): p. 2022-9. (483 citations)
  • Billerbeck, E., Y.H. Kang, L. Walker, H. Lockstone, S. Grafmueller, V. Fleming, J. Flint, C.B. Willberg, B. Bengsch, B. Seigel, N. Ramamurthy, N. Zitzmann, E.J. Barnes, J. Thevanayagam, A. Bhagwanani, A. Leslie, Y.H. Oo, S. Kollnberger, P. Bowness, O. Drognitz, D.H. Adams, H.E. Blum, R. Thimme, and P. Klenerman, Analysis of CD161 expression on human CD8+ T cells defines a distinct