VALIDATE Vaccines for Skin NTDs Seminars: Latest Vaccine Progress in the Field

About the Seminar

In this fourth seminar in the series, we will highlight recent advances in Buruli ulcer vaccine development and explore how spatial and single-cell transcriptomics are transforming vaccine design.

A Composite Subunit Vaccine Confers Full Protection Against Buruli Ulcer Disease in the Mouse Footpad Model of Mycobacterium ulcerans Infection
Prof Rajko Reljic, St George’s, University of London, UK

Rajko will present results from a recent study in which his team demonstrated that an experimental subunit vaccine combining mycolactone and protein antigens can provide complete protection against M. ulcerans infection in the mouse model. These findings mark an important step towards developing an effective vaccine against Buruli ulcer.

Dr Camila I de Oliveira, Fundação Oswaldo Cruz, Brazil

Attenuated parasites as a road for vaccine development against CL – roadblocks and advancements

In Brazil, Cutaneous Leishmaniasis (CL) is caused mainly by one species but is associated with a spectrum of clinical manifestations. In this talk, Camila will share results regarding the use of attenuated cell lines for vaccine development against CL caused by L. braziliensis. She will also discuss alternative scenarios and other advances currently underway to meet the challenges of vaccine testing and development.