Ravi Kant

Post-Doctoral Research Fellow (ICMR)

University of Delhi, India

VALIDATE Role:

Network Affiliate

Research Keywords:

Reverse Vaccinology, Immunoinformatics, Computational Drug Discovery, Drug Designing, Identification Characterization & Development of Potential Vaccine Candidates for Different Pathogens of Interest

Biography:

Dr. Ravi Kant, is a Post-Doctoral Research Fellow from Indian Council of Medical Research (ICMR) working at Dr.B.R.Ambedkar Center for Biomedical Research, University of Delhi-India. As a Computational Biologist, his main research interests focus on identifying novel drug targets, deciphering their mechanism of action and identifying the novel small molecule inhibitors to design & develop therapeutic drug and vaccine candidates.

More specifically, his main research responsibility is to use different aspects of Drug Discovery pipeline (Homology modelling, Pharmacophore generation, Molecular Docking and MD simulations) to identify and design lead molecules for Computer Aided Drug Designing for sexually transmitted infections, various kind of infectious diseases and targeting diverse set of pathogens. It is noteworthy that during his nine years of research journey, Ravi has been conferred with some of the prestigious awards during his research career like The Bill & Melinda Gates Foundation Fellowship(7 times), Young Investigator Award from India & Southeast Asia, Young Scientist Award(3 times) , Outstanding Research Scholar Award(2 times) and the most recent one The BBSRC-UKRI International Partnership Funding. While presenting his research findings & engaged in several collaborations across the globe Ravi has travelled 14 times till now to the countries like UK, United States, South Korea, Singapore, Canada, Thailand, South Africa, Germany and has demonstrated his quality research in the form of several research papers and novel findings applied for patents in India. The ongoing research projects have secured funding from some of the prime funding agencies in India (Indian Council of Medical Research, Department of Biotechnology, Government of India) & UK (BBSRC-UKRI International Partnership Funding from UK).

Related Websites:

Personal Website

Twitter

Key Publications:

Ravi Kant, (2016) Pharmacophore modelling, database mining and biological evaluation to identify novel structurally diverse compounds as potential anti-Ebola drugs. International Journal of Infectious Diseases. ISSN: 1201-9712 (Volume 45, Supplement 1): pp 178-179
Deepika Bhaskar, Chayanika Gujela, Kirti Goswami, Jyoti Pinghal, Swati Tripathi, Ravi Kant, (2016).Translational Approaches and Challenges for Personalized Cancer Medicine. International Journal of Basic and Applied Biology. ISSN: 2394-5820 (Volume 3, Issue 3): pp 192-196
Nikita Soni, Sunil Kumar Swain, Ravi Kant, Aditya Singh, Rahul Ravichandran, Suresh K Verma, Pritam Kumar Panda, Mrutyunjay Suar (2019). Landscape of ROD9 Island: Functional annotations and biological network of hypothetical proteins in Salmonella enterica. Journal of Computational Biology and Chemistry.
Ravi Kant, Prakash Jha, Alka Pawar , Madhu Chopra, Daman Saluja (2019). Targeting muri protein to combat drug resistance in neisseria gonorrhoeae using homology modelling and drug docking studies. Sexually Transmitted Infections 2019;95:A282.
Ravi Kant, Prakash Jha, Daman Saluja & Madhu Chopra (2022): Identification of novel inhibitors of Neisseria gonorrhoeae MurI using homology modelling, structure-based pharmacophore, molecular docking, and molecular dynamics simulation-based approach, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2022.2121943
Sawetaji, Shanky Jindal, Ravi Kant, Daman Saluja, Kamal Krishan Aggarwal (2023): Identification of thrombin inhibiting antithrombin –III like protein from Punica granatum using in silico approach and in vitro validation of thrombin inhibition activity in crude protein. Natural Product Research (GNPL) , DOI: 10.1080/14786419.2023.2169919.
Amaral, M.; Varela, M.T.; Kant, R.; Christodoulides, M.; Fernandes, J.P.S.; Tempone, A.G. Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi. Life 2023, 13, 663. https:// doi.org/10.3390/life13030663
Kaushik, R.; Kant, R.; Christodoulides, M.;. Mini Review : Artificial Intelligence in Accelerating vaccine development - Current and future perspectives. Frontiers in Bacteriology 2023, 2, 663. https:// doi: 10.3389/fbrio.2023.1258159
Alka Pawar, Chandrika Konwar, Prakash Jha, Ravi Kant, Madhu Chopra, Uma Chaudhary, Daman Saluja: Bactericidal activity of esculetin is associated with impaired cell wall synthesis by targeting glutamate racemase of Neisseria gonorrhoeae. Journal of Molecular Diversity (2023)
Ravi Kant, Rahul Kaushik, Madhu Chopra & Daman Saluja (2024) Structure-based drug discovery to identify SARS-CoV2 spike protein–ACE2 interaction inhibitors, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2023.2300060