Alba Llibre

Alba Llibre

Post-doctoral Researcher 

University of Birmingham, UK







Network Associate


Research Keywords: 

Tuberculosis, cytokine responses, immunometabolism



I am working as a post-doctoral researcher with a Marie Curie-Sklodowska Individual Fellowship at the University of Birmingham (UK). My main project focuses on the study of functional immune and metabolic responses to Mycobacterium tuberculosis (M.tb). Our project aims to better understand the interplay between immune responses and metabolism in the phenotype and function of macrophages. Understanding their dynamics will bring new insights into tuberculosis pathogenesis and can lead to the development of novel immunotherapies, targeting both immune and/or metabolic host cell pathways.


Related Websites: 

Profile page at University of Birmingham


Key Publications:

Rodrigues KB*, Dufort MJ*, Llibre A, Speake C, Rahman J, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV. Innate immune stimulation of whole blood reveals type 1 IFN hyper-responsiveness in type 1 diabetes. Diabetologia 2020. (Accepted).

Llibre A, Bilek N, Bondet V, Darboe F, Mbandi SK, Penn-Nicholosn A, Hatherill M, Rozenburg F, Scriba TJ, Duffy D. Plasma type I IFN protein concentrations in human tuberculosis. Front Cell Infect Microbiol 2019. doi: 10.3389/fcimb.2019.00296.

Duffy D, Nemes E, Llibre A, Rouilly V, Filander E, Africa H, Mabwe S, Jaxa J, Charbit B, Musvosvi M, Mulenga H, the Milieu Intérieur Consortium, Thomas S, Hatherill M, Bilek N, Scriba TJ, Albert ML. Immune profiling in M. tuberculosis infection enables stratification of patients with active disease. BioRxiv 2019.

GI Rice, C Meyzer, N Bouazza, M Hully, N Boddaert, M Semarero, LAH Zeef, F Rozenberg, V Bondet, D Duffy, A Llibre, J Baek, MN Sambe, E Henry, V Jolaine, C Barnerias, M Barth, A Belot, C Cances, G Debray, D Doummar, ML Frémond, N Kitabayashi, A Lepelley, V Levrat, I Melki, P Meyer, MC Nougues, F Renaldo, M Rodero, D Rodriguez, A Roubertie, L Seabra, C Uggenti, H Abdoul, JM Treluyer, I Desguerre, SBlanche, YJ Crow. Reverse transcriptase inhibitors in Aicardi-Goutières syndrome. N Engl J Med 2018. doi: 10.1056/NEJMc1810983.

Llibre A, Shimakawa Y, Duffy D. Potential utility of the Genedrive point-of-care test for HCV RNA detection. Gut 2018. doi: 10.1136/gutjnl-2018-317218.

Llibre A, Duffy D. Immune response biomarkers in human and veterinary research. Comp Immunol Microbiol Infect Dis 2018. doi: 10.1016/j.cimid.2018.09.008.

Llibre A*, Bondet V*, Rodero MP, Hunt D, Crow Y, Duffy D. Development and validation of an ultrasensitive single molecule array digital ELISA for human IFNα. J Vis Exp. 2018. IF: 1.12. doi: 10.3791/57421.

Llibre A*, Shimakawa Y*, Mottez E, Ainswroth S, Buivan TP, Firth R, Harrison E, Rosenberg AR, Meritet JF, Fontanet A, Castan P, Madejon A, Laverick M, Pol S, McClure P, Irving W, Miele G, Albert ML, Duffy D. Development and clinical validation of the Genedrive point-of-care test for qualitative detection of Hepatitis C virus. Gut 2018. doi: 10.1136/gutjnl-2017-315783.

Musvosvi M, Duffy D, Filander E, Hadn A, Mabwe S, Nkantsu L, Bilek N, Llibre A, Rouilly V, Hatherill M, Albert M, Scriba T, Nemes E. T cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation. Eur Respir J 2018. doi: 10.1183/13993003.00153-2018.

Llibre A, Garner L, Partridge A, Freeman G, Klenerman P and Willberg CB. Expression of Lectin-Like Transcript-1 in human tissues.  F1000Research 2016. doi: 10.12688/f1000research.10009.1

Llibre A, Klenerman P and Willberg CB. Multi-functional Lectin-Like Transcript-1: a new player in immune regulation. Immunol Lett 2016. doi: 10.1016/j.imlet.2016.07.007.

Llibre A, Lopez-Macias C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD, Walker LJ, Milne P, Phillips RE, Kelly DF, Freeman GJ, El Shikh ME, Klenerman P and Willberg CB. LLT1 and CD161 expression in human germinal centers promotes B cell activation and CXCR4 downregulation. J Immunol 2016. doi: 10.4049/jimmunol.1502462.

Fergusson JR, Huhn M, Swadling L, Walker L, Kurioka A, Llibre A, Newell EW, Davis MM, Bertoletti A, Hollander G, Sverremark E, Powrie F, Capone S, Folgori A, Barnes E, Willberg CB, Ussher J, Klenerman P. CD161int CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut. Mucosal Immunol. 2015. doi: 10.1038/mi.2015.69.