Chiraz Atri

Chiraz Atri

Post-doc Researcher

Institut Pasteur de Tunis, Tunisia

Email: chiraz_atri@yahoo.fr

 

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords:

Leishmania, Immune Response, Omics, Biomarkers

 

Biography:

Chiraz Atri is a post-doctoral researcher at Institut Pasteur de Tunis. She got her PhD in Biological Sciences on December 2018. With her hybrid scientific profile as a Biologist and Bioinformatician, Chiraz is involved in several funded projects dealing with infectious diseases, host-pathogen interactions and epidemiological surveillance. Chiraz started working on Cutaneous Leishmaniasis since 2011 during her master's internship and continued through her thesis and her post-doc. The main goal of her ongoing work, is to further investigate host-parasite interactions. More specifically, she is implicated in analysing the impact of Leishmania parasite infection on innate immune responses through genomics and transcriptomics features of hyper- and hypo-virulent isolates of parasites using high-throughput datasets. Chiraz studied the role played by microRNAs as regulators of gene expression as well as the role of their targets in human macrophages infected with Leishmania major parasites in order to identify biomarkers and molecules with anti-parasitic and/or vaccine potential.

 

Related Websites:

LinkedIn

 

Key Publications:

  • Ghedira K, Dallali H, Ardhaoui M, Bouslama Z, Hamdi Y, Fekih S, Chelbi H, Atri C, Chaouch M, DEKHIL N, Rais A, Azouz S, Gharbi M, Guerfali FZ, Hkimi C, Kamoun S, Ksouri A, Moumni I, Ouragini H, Bsibes R, Afifi Z, Youssfi K, Ben Hassine H, Hadhri N, Mardassi H, Othman H, Khamessi O. PHINDaccess Hackathons for COVID-19 and Host-Pathogen Interaction: Lessons Learned and Recommendations for Low- and Middle-Income Countries. BioMed Research International. e 2023, Article ID 6638714, 12 pages doi.org/10.1155/2023/6638714.
  • Ben-Cheikh A, Bali A, Guerfali FZ, Atri C, Attia H, Laouini D. Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence. Korean J Parasitol. 2022 Oct;60(5):317-325. doi: 10.3347/kjp.2022.60.5.317. Epub 2022 Oct 21. PMID: 36320108; PMCID: PMC9633161.
  • Attia H, Sghaier MR, Bali A, Guerfali FZ, Chlif S, Atri C, Belhaj-Hamida N, Zaatour A, Gharbi A, Ben-Salah A, Dellagi K, Laouini D. Intra-Specific Diversity of Leishmania major Isolates: A Key Determinant of Tunisian Zoonotic Cutaneous Leishmaniasis Clinical Polymorphism. Microorganisms. 2022 Feb 25;10(3):505. doi: 10.3390/microorganisms10030505. PMID: 35336081; PMCID: PMC8955835.
  • Chouikha A, Fares W, Laamari A, Haddad-Boubaker S, Belaiba Z, Ghedira K, Kammoun Rebai W, Ayouni K, Khedhiri M, Ben Halima S, Krichen H, Touzi H, Ben Dhifallah I, Guerfali FZ, Atri C, Azouz S, Khamessi O, Ardhaoui M, Safer M, Ben Alaya N, Guizani I, Kefi R, Gdoura M, Triki H. Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19. Viruses. 2022 Mar 17;14(3):624. doi: 10.3390/v14030624. PMID: 35337031; PMCID: PMC8956073. - MicroRNAs in diagnosis and therapeutics. (2019) Atri C, Guerfali FZ, Laouini D. In AGO-driven-Non-Coding RNAs 2019. Academic Press. (pp. 137-177)
  • Atri C, Guerfali FZ, Laouini D. Role of Human Macrophage Polarization in Inflammation during Infectious Diseases. Int J Mol Sci. 2018 Jun 19;19(6):1801. doi: 10.3390/ijms19061801. PMID: 29921749; PMCID: PMC6032107.
  • Ghouila A, Guerfali FZ, Atri C, Bali A, Attia H, Sghaier RM, Mkannez G, Dickens NJ, Laouini D. Comparative genomics of Tunisian Leishmania major isolates causing human cutaneous leishmaniasis with contrasting clinical severity. Infect Genet Evol. 2017 Jun;50:110-120. doi: 10.1016/j.meegid.2016.10.029. Epub 2016 Nov 4. PMID: 27818279; PMCID: PMC5376240.
  • Attia H, Bali A, Sghaier RM, Leon Martinez PA, Mkannez G, Atri C, Chourabi K, Guerfali FZ, Laouini D. Comparison Between Plethysmometer and Caliper Methods to Monitor Lesion-Size Induced by Leishmania major Infection in BALB/c Mouse Experimental Model, Animal and Veterinary Sciences. 2015; 3(6): 179-185. doi: 10.11648/j.avs.20150306.16