Faith Thole

Faith Thole

Research Assistant

Malawi-Liverpool-Wellcome Programme, Malawi

Email: fthole@mlw.mw

 

 

 

 

VALIDATE Role:

Network Affiliate

 

Research Keywords:

Controlled Human challenge Models in TB and Streptococcus Pneumoniae pathogens

 

Biography:

I am a Medical Laboratory Scientist with a strong interest in vaccine development research, I have worked with the Malawi Accelerated Research in Vaccines, Experimental and laboratory Systems (MARVELS) project as a laboratory-based Research Assistant. My experience includes working on Controlled Human Challenge Models (CHIM). Some works focusing on Streptococcus pneumoniae involved dose-ranging studies on serotypes 3 and 6B, assessing the efficacy of the PCV13 vaccine in Malawi, and examining the MV130 intervention and CHIM in individuals living with HIV.

I am now working on Controlled Human Infection Models involving Mycobacterium tuberculosis that is looking at BCG Dose ranging, recovery from sites of inoculation as well as immunological responses post inoculation.

 

Key Publications:

  • Effect of 13-valent pneumococcal conjugate vaccine on experimental carriage of Streptococcus pneumoniae serotype 6B in Blantyre, Malawi: a randomised controlled trial and controlled human infection study
  • Natural Carriage of Streptococcus pneumoniae Is Associated With Increased Experimental Pneumococcal Carriage but Reduced Conjugate Vaccine Efficacy in a Human Challenge Model
  • Experimental Human Pneumococcal Carriage using Streptococcus pneumoniae serotype 3 in Malawi: a dose ranging and reproducibility human infection study