Ioannis Kourtzelis
Lecturer in Immunology Hull York Medical School & University of York, United Kingdom (UK) Email: ioannis.kourtzelis@york.ac.uk
VALIDATE Role: Network Associate
Research Keywords: Leishmania, Macrophages, Phagocytosis, Innate Immunity, Immune Modulation, Parasites
Biography: A hallmark function of the immune system during inflammation is the recognition and removal of any ‘foreign’ material by phagocytosis ensuring timely return to homeostasis. Phagocytosis contributes to the removal of millions of cells during inflammation daily and is extremely important in disease resolution (Kourtzelis et al, Nature Immunology 2019). Impaired phagocytosis results in chronic destructive inflammation and disease development including sterile inflammation, infectious diseases or cancer. Myeloid cells are professional ‘eaters’ mediating the well coordinated phagocytosis of different types of cargo such as pathogens, tumour cells and dying cells. My current research interests include the regulation of myeloid cell function during the onset and resolution phase of sterile and pathogen-induced inflammatory responses as well as the orchestration of anti-tumour immunity. Our lab applies an integrated set of approaches that include in vitro co-culture assays, preclinical in vivo models, together with the analysis of patient samples to provide a holistic understanding of myeloid cell phenotypic adaptations in human diseases.
Related Websites: You are what you eat - harnessing myeloid cell activity to promote disease clearance
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