John E. Pearl

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Lecturer

University of Leicester

Email: jep38@leicester.ac.uk

Tel: 44 (0)116 229 7910

 

 

 

 

VALIDATE Role: Netowrk Affiliate
 

Research Keywords

TB, NTM, animal models, immunology, microbiology
 

 

Key Publications

  • Pearl JE, Das M, Cooper AM. Immunological roulette: Luck or something more? Considering the connections between host and environment in TB. Cell Mol. Immunol. 2018 Mar;15(3):226-232. doi: 10.1038/cmi.2017.145. Epub 2018 Jan 29. PMID: 29375129; PMCID: PMC5843621.
  • Sulman S, Savidge BO, Alqaseer K, Das MK, Nezam Abadi N, Pearl JE, Turapov O, Mukamolova GV, Akhtar MW, Cooper AM. Balance between Protection and Pathogenic Response to Aerosol Challenge with Mycobacterium tuberculosis (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens. Vaccines (Basel). 2021 May 18;9(5):519. doi: 10.3390/vaccines9050519. PMID: 34070048; PMCID: PMC8158147.
  • Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, PearlJE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK,Strutt TM, Wilkinson RJ, Swain SL, Cooper AM. Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosisinfection. J Exp Med. 2015 Aug 24;212(9):1449-63. doi: 10.1084/jem.20141520. Epub 2015 Aug 17. PMID: 26282876; PMCID: PMC4548054.
  • Torrado E, Fountain JJ, Robinson RT, Martino CA, Pearl JE, Rangel-Moreno J, Tighe M, Dunn R, Cooper AM. Differential and site specific impact of B cells inthe protective immune response to Mycobacterium tuberculosis in the mouse. PLoS One. 2013 Apr 16;8(4):e61681. doi: 10.1371/journal.pone.0061681. PMID: 23613902; PMCID: PMC3627912.
  • Pearl JE, Torrado E, Tighe M, Fountain JJ, Solache A, Strutt T, Swain S, Appelberg R, Cooper AM. Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection. Eur J Immunol. 2012 Dec;42(12):3267-79. doi: 10.1002/eji.201142158. Epub 2012 Sep 26. PMID: 22890814; PMCID: PMC3664054.