Professor and Head of Microbiology
Christian Medical College, India
Tel: +91 416-2282588
Tuberculosis diagnostics: drug resistance, latent infection, latent infection, reinfection, reactivation, infection in HIV and point of care testing approaches
I am a clinical microbiologist with interests in tuberculosis, candidiasis and invasive fungal infections and hospital infection control.
After completing formal training in India and the UK, I have been involved in teaching, diagnostics and research in India for over a decade. I also chair the Hospital Infection Control Committee, one of the first to be set up in the country. I am part of the Technical Expert Group on diagnosis of Tuberculosis for India since 2018 and in this role, provide technical guidelines for diagnosis and management of all forms of tuberculosis for the country.
Boehme CC, Nicol MP , Nabeta P, Michael J S, Gotuzzo E, Tahirli R, Gler MT et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet. Apr 30, 2011; 377(9776): 1495– 1505.
Vassall A, van Kampen S, Sohn H, Michael JS, John KR, et al. (2011). Rapid Diagnosis of Tuberculosis with the Xpert MTB/RIF Assay in High Burden Countries: A Cost-Effectiveness Analysis. PLoS Med 8(11): e1001120. doi:10.1371/journal.pmed.1001120
Govindaswamy A, Sakthi D, Pai R, Jeyaseelan L, Michael JS. Pyrosequencing: a rapid and effective sequencing method to diagnose drug-resistant tuberculosis. J Med Microbiol. 2018 Sep;67(9):1212-1216. doi: 10.1099/jmm.0.000669. Epub 2018 Jul 20. PubMed PMID: 30028665.
Mathuram AJ, Michael JS, Turaka VP, Jasmine S, Carey R, Ramya I. Mycobacterial blood culture as the only means of diagnosis of disseminated tuberculosis in advanced HIV infection. Trop Doct. 2018 Apr;48(2):100-102. doi: 10.1177/0049475517747491. Epub 2017 Dec 13. PubMed PMID: 29235968.
Arockiaraj J, Balaji GS, Cherian VM, T S J, Thomas BP, Michael JS, Poonnoose PM. Drug resistant Skeletal Tuberculosis in a tertiary care centre in South India. J Clin Orthop Trauma. 2018 Mar;9(Suppl 1):S44S48. doi: 10.1016/j.jcot.2017.12.009. Epub 2017 Dec 29. PubMed PMID: 29628698; PubMed Central PMCID: PMC5883913.
Suzana S, Shanmugam S, Uma Devi KR, Swarna Latha PN, Michael JS. Spoligotyping of Mycobacterium tuberculosis isolates at a tertiary care hospital in India. Trop Med Int Health. 2017 Jun;22(6):703-707. doi: 10.1111/tmi.12875. Epub 2017 May 4. PubMed PMID: 28374900
Ninan MM, Gowri M, Christopher DJ, Rupali P, Michael JS. The diagnostic utility of line probe assays for multidrug-resistant tuberculosis. Pathog Glob Health. 2016 Jun-Jul;110(4-5):194-9. doi: 10.1080/20477724.2016.1214350. Epub 2016 Aug 8. PubMed PMID: 27499239; PubMed Central PMCID: PMC5072114.
Suzana S, Ninan MM, Gowri M, Venkatesh K, Rupali P, Michael JS. Xpert MTB/Rif for the diagnosis of extrapulmonary tuberculosis--an experience from a tertiary care centre in South India. Trop Med Int Health. 2016 Mar;21(3):385-92. doi: 10.1111/tmi.12655. Epub 2016 Jan 19. PubMed PMID: 26671654.