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Visiting Professor
Instituto Butantan, Brazil
VALIDATE Role:
Network Associate
Research Keywords:
TB, Systems Biology, Immunology, Vaccinology
Biography:
My research hubs on tuberculosis vaccinology at the interface of systems immunology, microbiology, and applied vaccinology. I am focused in develop more efficient vaccines, understanding the innate and adaptive immune signatures of protection and broadening the focus beyond classical Th1/Th17 paradigms to diversify TB vaccine concepts and deliver reliable readouts capable of protect against infection or disease progression. Current priorities include: (1) defining correlates of protection by integrating high‑dimensional serology with functional assays and systems‑level analytics; (2) advancing vaccine constructs of rational adjuvant and approaches to optimize the quality, breadth, and durability of responses; and (3) translating antigen‑discovery pipelines into deployable diagnostics that strengthen TB control in high‑burden settings. Through collaborations across vaccinology and systems biology, and by mentoring graduate trainees, I aim to convert mechanistic insights into practical interventions, vaccines and diagnostics, that accelerate progress toward TB elimination.
Related Websites:
LinkedIn
Key Publications:
- Marques-Neto LM, Trentini MM, Moreno ACR, Eto SF, Carvalho ACO, Neto APS, Amaral MS, Martins AGC, Gonçalves ANA, Chudzinski-Tavassi AM, Kanno AI, Tagliabue A, Boraschi D, Verjovski-Almeida S, Nakaya H, Farias LP, Ramos PIP and Leite LCC (2025) rBCG-LTAK63 enhances Protection against tuberculosis by inducing autophagy and circadian gene regulation. Front. Immunol. 16:1695560. doi: 10.3389/fimmu.2025.1695560
- Woellner-Santos D, Tahira AC, Malvezzi JVM, Mesel V, Morales-Vicente DA, Trentini MM, Marques-Neto LM, Matos IA, Kanno AI, Pereira ASA, Teixeira AAR, Giordano RJ, Leite LCC, Pereira CAB, DeMarco R, Amaral MS, Verjovski-Almeida S. Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in selfcured rhesus macaques. NPJ Vaccines. 2024 Jan 4;9(1):5. doi: 10.1038/ s41541-023-00803-x. PMID: 38177171; PMCID: PMC10767053.
- Marques-Neto LM, Trentini MM, Kanno AI, Rodriguez D, Leite LCC. Recombinant BCG expressing the LTAK63 adjuvant increased memory T cells and induced long-lasting protection against Mycobacterium tuberculosis challenge in mice. Front Immunol. 2023 Jul 13;14:1205449. doi:10.3389/fimmu.2023.1205449. PMID: 37520577; PMCID:PMC10374402.
- Trentini, Monalisa Martins; Kanno, Alex Issamu; Rodriguez, Dunia; Marques-Neto, Lazaro Moreira ; Eto, Silas Fernandes; Chudzinski-Tavassi, Ana Marisa; Leite, Luciana Cezar de Cerqueira. Recombinant BCG expressing the LTAK63 adjuvant improves a short-term chemotherapy schedule in the control of tuberculosis in mice. Frontiers in Immunology, v. 13, p. 13:943558, 2022. doi:10.3389/fimmu.2022.943558. PMID: 36119106; PMCID: PMC9471321.
- Neto, Lázaro Moreira Marques; Zufelato, Nicholas; de Sousa-Júnior, Ailton Antônio; Trentini, Monalisa Martins; da Costa, Adeliane Castro; Bakuzis, Andris Figueiroa; Kipnis, André; Junqueira-Kipnis, Ana Paula. Specific T cell induction using iron oxide based nanoparticles as subunit vaccine adjuvant. Human Vaccines & Immunotherapeutics, v. 1, p. 1-56, 2018. doi: 10.1080/21645515.2018.1489192. Epub 2018 Jul 12. PMID:29913109; PMCID: PMC6314432.
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