Madhurima Roy
Senior Research Fellow Institute of Post Graduate Medical Education & Research (IPGME&R), Kolkata Email: madsroy296@gmaiI.com
VALIDATE Role: Network Affiliate
Research keywords: Indian Leishmaniasis, immuno-pathology. diagnostics
Biography: Working on clinical diagnostics and immunology of Visceral Leishmaniasis (VL) and Post Kala-azar Dermal Leishmaniasis (PKDL), neglected infectious diseases. As part of diagnostics, I have worked in understanding the potential of amastigote-specific genes in the identification of Leishmania donovani by droplet digital PCR in various models of Leishmaniasis. Additionally, I have also evaluated the potential of Recombinase Polymerase Amplification assay (RPA) to monitor parasite load in Visceral and Post Kala-azar Dermal Leishmaniasis and the potential of next-generation Nanopore sequencing technology in the identification of Leishmania species. The immune-pathology work is primarily on biological material sourced from patients with Post Kala-azar dermal Leishmaniasis and has identified neutrophils, a component of an innate immune cell to be persisting and possible interactions of human neutrophils with keratinocytes in facilitating the persistence of infection in the chronic PKDL scenario. Moreover, there is evidence of neutrophils forming neutrophil-dendritic cell hybrids in the circulation of patients with PKDL. The significance of these findings potentially serves as important cues to resolve future mechanistic studies for guiding clinical research and development of chemotherapeutic strategies.
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