Patricia Grace
Assistant Professor University of Pittsburgh, United States of America (USA) Email: patricia.grace@pitt.edu
VALIDATE Role: Network Associate
Research Keywords: TB, Biomarkers, Animal Models, Antibody-Mediated Immune Function
Biography: Antibodies are a powerful and adaptive feature of the immune system that can coordinate potent protective responses during infection. Canonically viewed as antigen specific effectors that neutralize extracellular virus via the antigen binding (Fab) domain, the antibody constant (or Fc-) domain also contributes to pathogen control via interactions with complement or Fc receptors (FcR) expressed on immune cells. Antibodies are a key immune feature that links the TB pathogen to innate and adaptive immunity. The Grace lab uses human and mouse models to identify humoral immune correlates in TB patients associated with favourable infection outcomes and define the antibody-mediated mechanisms that promote bacterial restriction by immune cells. Using antibodies as tools to perturb the immune system, we hope to identify novel immune responses that contribute to TB control.
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