Simone Weyand

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Independent Scientist

University of Cambridge, United Kingdom (UK)

Email: sw644@cam.ac.uk

 

 

 

 

VALIDATE Role:

Network Affiliate

 

Research Keywords:

TB and other mycobacterial strains, Trypanosomes and Leishmania, Front end vaccine design which is structure and deep sequencing based so get the optimal set of sequences for broad coverage

 

Biography:

I have studied Biochemistry and molecular genetics in my undergraduate and continued my PhD at the EMBL to learn structural biology. I have performed my first postdoc at the Imperial College London and my second postdoc at the MRC-LMB. I then set up my own independent group at the University of Cambridge where I am an independent scientist now. 

 

Key Publications:

  • Matusevicius, M., Corey, R.A., Gragera, M., Yamashita, K., Sprenger, T., Ungogo, M.A., Blaza, J.N., Castro-Hartmann, P., Chirgadze, D., Y., Chaitania, V.S., Afanasyev, P., Melero, R., Warshamanage,, R., Carazo, J.M., Carrington, M., Blundell, T.L., Murshudov, G., Stansfeld, P., Sansom, M., de Koning., H.P., Tate, C.G. and Weyand, S.N. (2023): Insights from aquaporin structures into drug-resistant sleeping sickness. (Under review at Nature communications.)
  • Gusach, A., Lee, Y., Khoshgrudi, A.N., Mukhaleva, E., Ma, N., Koers, E.J., Chen, Q., Edwards, P.C., Huang, F., Kim, J., Mancia, F., Verprintsev, D.B., Vaidehi, N., Weyand, S.N. and Tate, C.G. (2023): Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f. bioRxiv. Doi: 10.1101/2023.07.07.547762. (Under review by Nature Communications)
  • Alghamdi, A.H., Munday, J.C., Campagnaro, G.D., Gurvic, D., Svensson, F., Okpara, C.E., Kumar, A., Quintana, J., Martin Abril, M.E., Milić, P., Watson, L., Paape, D., Settimo, L., Dimitriou, A., Wielinska, J., Smart, G., Anderson, L.F., Woodley, C.M., Kelly, S.P.Y., Ibrahim, H.M., Hulpia, F., Al-Salabi, M.I., Eze, A.A., Sprenger, T., Teka, I.A., Gudin, S., Weyand, S., Field, M., Dardonville, C., Tidwell, R.R., Carrington, M., O'Neill, P., Boykin, D.W., Zachariae, U., De Koning and H.P. (2020): Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei. Elife. 9:e56416.
  • Shimamura,*, T., Weyand, S.*, Beckstein, O.*, Rutherford, N.G., Hadden, J.M., Sharples, D., Sansom, M.S.P, Iwata, S., Henderson, P.J.F. and Cameron, A.D. (2010): Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1, Science, 328, 470-475. (Faculty of 1000).
  • Weyand, S.*, Shimamura, T.*, Yajima, S.*, Suzuki, S.*, Mirza, O.*, Krusong, K., Carpenter, E. P., Rutherford, N. G., Hadden, J. M., O’Reilly, J., Ma, P., Saidijam, M., Patching, S. G., Hope, R. J., Norbertczak, H. T., Roach, P. C. J., Iwata, S., Henderson, P. J. F. and Cameron, A. D. (2008) Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science. 322, 709-713.