Sudhakar Natarajan

Sudhakar Natarajan

Scientist C

ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT), India

Email: sudhakar.na@icmr.gov.in

 

 

 

 

VALIDATE Role: Pending

 

Research Keywords

TB, HIV, Emerging viral infections, One Health, Vaccines for TB/HIV

 

Biography

Dr. Sudhakar Natarajan, Ph.D., is a Scientist ‘C’ working in the Department of Virology and Biotechnology at National Institute for Research in Tuberculosis (NIRT), Chennai, India. He has completed his Ph.D in Molecular Oncology. His Ph.D thesis titled “Molecular analysis ofT-cell receptor (TCR) and Immunoglobulin heavy chain (IgH) gene rearrangements in Acute Lymphoblastic Leukemia”. He has a post- doctoral stint at National Cancer Institute (NCI), Frederick, USA. He is a Co-Investigator in the establishment of Viral Research and Diagnostic Laboratories (VRDL) facility at NIRT, which has been funded by Department of Health Research, Govt. of India. His research interests include Molecular biology & Molecular Virology, Genomics & Transcriptomics of Tuberculosis (TB), HIV, COVID-19, and emerging infectious diseases. He is also working on Development and Validation of a diagnostic kit for early detection of Human papilloma virus (HPV) infection in Cervical cancer. He has more than 20 publications in peer- reviewed journals to his credit.

 

Related websites

 

Key Publications

  • Natarajan S, Ranganathan M, Natarajan PL, Nesakumar M, Anbalagan S, Lucia Precilla K, Hemalatha H, Kannan M, Narendran G, Mahalakshmi S, Karmegam G, Prakash L, Narayanasamy K, Hanna LE. Comparison of Real-time RT-PCR cycle threshold (Ct) values with clinical features and severity of COVID-19 disease among hospitalized patients in the first and second waves of COVID-19 pandemic in Chennai, India. J Clin Virol Plus. 2023 Jun;3(2):100146. doi: 10.1016/j.jcvp.2023.100146.
  • Kumar THV, Srinivasan S, Krishnan V, Vaidyanathan R, Babu KA,
  • Natarajan S, Veerapandian M. Peptide-based direct electrochemical detection of receptor binding domains of SARS-CoV-2 spike protein in pristine samples. Sens Actuators B Chem. 2023 Feb 15; 377:133052. doi:
  • 10.1016/j.snb.2022.133052. Epub 2022 Nov 23. PMID: 36438197; PMCID: PMC9682882.
  • Sudhakar Natarajan, Mohan Ranganathan, Luke Elizabeth Hanna, Srikanth Tripathy. Transcriptional Profiling and Deriving a Seven-Gene Signature That Discriminates Active and Latent Tuberculosis: An
  • Integrative Bioinformatics Approach. Genes 2022, 13(4),
  • 616; https://doi.org/10.3390/genes13040616
  • Daniel EA, Esakialraj L BH, S A, Muthuramalingam K, Karunaianantham R, Karunakaran LP, Nesakumar M, Selvachithiram M, Pattabiraman S,
  • Natarajan S, Tripathy SP, Hanna LE. Pooled Testing Strategies for SARS-
  • CoV-2 diagnosis: A comprehensive review. Diagn Microbiol Infect Dis. 2021 May 17;101(2):115432. doi: 10.1016/j.diagmicrobio.2021.115432. PMID: 34175613; PMCID: PMC8127528.
  • Natarajan S, Ranganathan M. Toll-like receptor (TLR) gene expression and immunostimulatory effect of CpG oligonucleotides in hormone receptor positive cell line T47D and triple negative breast cancer cell line MDA-MB- 468. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):408-415. doi: 10.1080/08923973.2020.1797779. Epub 2020 Aug 6. PMID: 32686546.
  • Mohan R, Luke Elizabeth Hanna, Srikanth P Tripathy, Sudhakar N. Bioinformatics analysis of microarray data for identifying the differentially expressed host genes in Active tuberculosis (ATB) compared to Latent tuberculosis (LTB) infection. BMC Infectious Diseases 2020, 20 (Suppl 1): ISSHID [Abstract]
  • Natarajan S, Sumantran VN, Ranganathan M, Madheswaran
  • Microarray and pattern miner analysis of AXL and VIM gene networks in
  • MDA-MB-231 cells. Mol Med Rep. 2018 Oct;18(4):4147-4155. doi:
  • 10.3892/mmr.2018.9404.
  • Sumantran VN, Mishra P, Bera R, Sudhakar N. Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma. Pharmaceutics. 2016 Feb 17;8(1):4. doi: 10.3390/pharmaceutics8010004. PMID: 26901218; PMCID: PMC4810080.
  • Sudhakar N, Priya Doss CG, Thirumal Kumar D, Chakraborty C, Anand K, Suresh M. Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach. J Biomol Struct Dyn. 2016;34(1):29-41. doi: 10.1080/07391102.2015.1007483. Epub 2015 Feb 13. PMID: 25679319.
  • Sumantran VN, Mishra P, Sudhakar N. Microarray analysis of differentially
  • expressed genes regulating lipid metabolism during melanoma
  • progression. Indian J Biochem Biophys. 2015 Apr;52(2):125-31. PMID:
  • 26118123..
  • Sudhakar N. Whether molecular genetic analysis is sufficient enough in prediction of an amino acid substitution in a protein as a variant or
  • deleterious mutation? Appl Immunohistochem Mol Morphol. 2015
  • Mar;23(3):236-7. doi: 10.1097/PAI.0000000000000038. PMID:
  • 25153501.
  • Sudhakar N, Theivanai Vidhya RM. (2014) Potential Medicinal properties of Carica papaya Linn - A mini review. International Journal of Pharmacy and Pharmaceutical Sciences 2014; Vol 6 (Issue 2): 1-4.
  • Natarajan Sudhakar, Kamalalayam Raghavan Rajalekshmy, Thangarajan Rajkumar, Karunakaran Nirmala Nancy. RT-PCR and Real-time PCR
  • Analysis of E2A-PBX1, TEL-AML1, mBCR-ABL and MLL-AF4 Fusion Gene
  • Transcripts in de novo B-Lineage Acute Lymphoblastic Leukemia Patients in South India. Journal of Genetics. 2011 Aug;90(2):349-53.
  • Natarajan Sudhakar, Nirmala K Nancy, Rajalekshmy K R, Raman S G, Rajkumar T. T-cell receptor Gamma and Delta gene rearrangements and Junctional region characteristics in South Indian patients with T-cell Acute Lymphoblastic Leukemia. American Journal of Hematology 2007; 82(3): 215-221.