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Postdoctoral Fellow
Stellenbosch University, South Africa
Email: suventha@sun.ac.za
VALIDATE Role:
Network Associate
Research Keywords:
Clinical trials, Microbiome, Antimicrobial Resistance
Biography:
My research interest is focused on the association of the microbiome with clinical outcome of tuberculosis. My research interesting are embedded in multiple research projects within CLIME looking at the microbiome’s influence in 1) Latent TB, 2) Short chain fatty acid production, 3) Anti-microbial resistance and 4) Aerosol composition. I’m also involved in the managing the project logistics and data analysis.
Related Websites:
Stellenbosch University
Key Publications:
- Moodley, S., Koorbanally, N. A., Moodley, T., Ramjugernath, D., & Pillay, M. (2014). The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay is a rapid, cheap, screening test for the in vitro anti-tuberculous activity of chalcones. Journal of microbiological methods, 104, 72-78.
- Naidoo C.C, Nyawo G.R, Sulaiman I, Turner C, Palmer Z, Li Y, Wu B.G, Reeve B.W.P, Moodley S, Jackson J.G, Limberis J, Warren R.M, Clemente J.C, Noursadeghi M, Segal L.N, Theron G. Pulmonary tuberculosis patients have an anaerobe-enriched microbiota associated with a pro-inflammatory peripheral host immune transcriptional phenotype. Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis. EBioMedicine. 2021 May 1;67:103374.
- Singh, S., Allwood, B.W., Chiyaka, T.L., Kleyhans-Cornelissen, L., Naidoo, C.C., Moodley, S., Theron, G. and Segal, L.N., 2022. Immunologic and imaging signatures in post tuberculosis lung disease. Tuberculosis, p.102244.
- Nyawo GR, Naidoo CC, Wu B, Sulaiman I, Clemente JC, Li Y, Minnies S, Reeve BW, Moodley S, Rautenbach C, Wright C. More than Mycobacterium tuberculosis: site-of-disease microbial communities, and their functional and clinical profiles in tuberculous lymphadenitis. Thorax. 2022 Dec 8.
- Moodley, S., Porter, T., Naidoo, C., Tshivhula, H., Folkerts, M., Bowers, J., Engelthaler, D. and Theron, G., 2023. PA-788 Can we escape ESKAPE bacteria: trends of antimicrobial resistance and single nucleotide polymorphisms in ESKAPE Bacteria in stool during and post TB treatment. BMJ Global Health 2023;8:A123. https://doi.org/10.1136/bmjgh-2023-EDC.301
- Moodley, S., Kroon, E., Naidoo, C.C., Nyawo, G.R., Wu, B.G., Naidoo, S., Chiyaka, T.L., Tshivhula, H., Singh, S., Li, Y. and Warren, R.M., 2024. Latent tuberculosis infection is associated with an enrichment of short chain fatty acid producing bacteria in the stool of women living with HIV. Microorganisms 2024, 12(6), 1048. https://doi.org/10.3390/microorganisms12061048
- Chiyaka, T.L., Nyawo, G.R., Naidoo, C., Moodley, S., Clemente, J.C., Malherbe, S.T., Warren, R., Ku, D., Segal, L.N. and Theron, G., 2024. PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculosis. Annals of Clinical Microbiology and Antimicrobials. 2024 Aug 22;23(1):74.https://doi.org/10.1186/s12941-024-00735-x
- Nyawo G, Naidoo CC, Wu BG, Kwok B, Clemente JC, Li Y, Minnies S, Reeve B, Moodley S, John TJ, Karamchand S. Bad company? The pericardium microbiome in people investigated for tuberculous pericarditis in an HIV-prevalent setting. Microbes and Infection. 2024 Nov 9:105434. https://doi.org/10.1016/j.micinf.2024.105434
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