Zaynab Mousavian Poster 2025

Dr Zaynab Mousavian

Karolinska Institute, Sweden

Plasma Protein Signatures for Active TB Diagnosis: 6-Marker and 4-Marker Panels as Promising Clinical Candidates

Poster Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a bacterial infectious disease with the highest number of deaths each year from an infection. A non-sputum-based biomarker for the early diagnosis of TB disease is urgently needed to control the spread of the disease to others, and without such a biomarker, achieving the World Health Organization (WHO)'s goals for ending TB will remain unattainable.

We previously introduced a 12-marker plasma protein signature for active TB diagnosis that was associated with disease severity. This study aims to validate the performance of this 12-marker signature in new independent cohorts and to further condense it to a smaller signature that is more cost-effective and better suited for clinical use. In this study, we introduce two promising 6-marker and 4-marker plasma protein signatures for active TB diagnosis, which also show better performance than other published signatures.