Zaynab Mousavian Poster 2025

×

Warning message

  • Could not find a Solr index corresponding to your website and environment. To fix this problem, please read our documentation.
  • Could not find a Solr index corresponding to your website and environment. To fix this problem, please read our documentation.
Zaynab Mousavian

Dr Zaynab Mousavian

Karolinska Institute, Sweden

Plasma Protein Signatures for Active TB Diagnosis: 6-Marker and 4-Marker Panels as Promising Clinical Candidates

 

Poster Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a bacterial infectious disease with the highest number of deaths each year from an infection. A non-sputum-based biomarker for the early diagnosis of TB disease is urgently needed to control the spread of the disease to others, and without such a biomarker, achieving the World Health Organization (WHO)'s goals for ending TB will remain unattainable.

We previously introduced a 12-marker plasma protein signature for active TB diagnosis that was associated with disease severity. This study aims to validate the performance of this 12-marker signature in new independent cohorts and to further condense it to a smaller signature that is more cost-effective and better suited for clinical use. In this study, we introduce two promising 6-marker and 4-marker plasma protein signatures for active TB diagnosis, which also show better performance than other published signatures.