The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens
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Funded Pump-priming Projects

VALIDATE funds pump-priming grants for research projects aiming to accelerate vaccine development for our focus pathogens. You can find out about applying on the Pump Priming Grants page. Below are the current and past pump-priming projects funded by VALIDATE.

 

 

Grant call round #6 - March 2025

Luciana Balboa

Accelerating BCG Efficacy: Targeting Dendritic Cell Migration in Tuberculosis Immunization

Dr Luciana Balboa, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Argentina
Suraj Bhattarai

Burden of Burkholderia pseudomallei in Nepal to inform vaccine needs (BURNEP study)

Dr Suraj Bhattarai, Global Health Research & Medical Interventions Institute (GLOHMED), Nepal
Julen Tomás Cortázar

Development of Versatile and Cost-Effective Next-Generation Vaccines through Multivalent Approaches

Dr Julen Tomás Cortázar, University College Dublin, Ireland
Mrinal Das

Determining the metabolic impact of BCG vaccination

Dr Mrinal Kumar Das, University of Leicester, UK
Alba Llibre Serradell

Profiling the mycobacterial immune response in human lung tissue to inform novel TB vaccine design

Dr Alba Llibre Serradell, University of Birmingham, UK
Menberework Negatue

Immune Signatures of Chronic Tuberculosis and Cutaneous Leishmaniasis

Dr Menberework Chanyalew Negatue, Armauer Hansen Research Institute (AHRI), Ethiopia
Mark Shiburah

Assessing the immunogenicity and protective efficacy of a telomerase deficient Leishmania major

Dr Mark Ewusi Shiburah, Council for Scientific and Industrial Research (CSIR), Ghana
VALIDATE Member Photo

CCR4LEP: Exploring CCR4 as immune correlate of protection for leprosy

Dr Anouk van Hooij, Leiden University Medical Center (LUMC), Netherlands
Gabriel Wagner-Lichtenegger

Melio MuSe: Multiplex Serology advancing multicomponent melioidosis vaccines

Dr Gabriel Wagner-Lichtenegger, Medical University of Graz, Austria
Andy Tran

Comparative testing of Ag85 isoforms and consensus sequence optimisation for next-gen TB vaccines

Dr Andy Tran, City St George's, University of London, UK

Grant call round #5 - March 2022

Ana Valencia-Hernandez

Evaluation of BCGΔBCG1419c::ESAT6-PE25SS in immunocompetent and immunocompromised mouse models of TB

Dr Ana Maria Valencia Hernandez, James Cook University, Australia
Laura Sibley

Characterising the cytokines associated with trained innate immunity in BCG vaccinated non-human primates

Dr Laura Sibley, UKHSA, UK
Munyaradzi Musvosvi

Towards a T cell subset that can control Mycobacterium tuberculosis infection

Dr Munyaradzi Musvosvi, University of Cape Town, South Africa
Paula Niewold

Towards a better TB vaccine: understanding improved local immune control by mucosal BCG vaccination

Dr Paula Niewold, LUMC, Netherlands
diane lee

Alvacc: A human in vitro alveolus model to study aerogenic TB vaccine binding and translocation

Dr Diane Lee, University of Surrey, UK
Andy Tran

Testing a novel, self-adjuvanting mucosal vaccine candidate for TB in the mouse model of infection

Dr Andy Tran, St George's, University of London, UK

Grant call round #4 - November 2019

Justice Boakye-Appiah

Cross protection against TB by attenuated Mycobacterium ulcerans strain 5114

Dr Justice Boakye-Appiah, SGUL, UK
Chiranjay Mukhopadhyay

Characterising the cellular immunity and metabolic response to Mycobacterium tuberculosis and Burkholderia pseudomallei in Indian patients for vaccine design

Prof Chiranjay Mukhopadhyay, Manipal Academy of Higher Education, India
Gabriele Pollara

T cell receptor sequencing to identify correlates of protection in human tuberculosis vaccine studies

Dr Gabriele Pollara, UCL, UK
Matthew Rogers

Modelling the impact of a transmission blocking vaccine against leishmaniasis on sand fly vectorial capacity

Dr Matthew Rogers, LSHTM, UK
Samantha Sampson

An ex vivo model for understanding the impact of vaccination on Mycobacterial persister populations

Prof Samantha Sampson, Stellenbosch University, South Africa
Iman Satti

Investigating the BCG-induced Natural Killer (NK) cell response in cattle and humans

Dr Iman Satti, University of Oxford, UK
Lisa Stockdale

Cytomegalovirus as a risk factor for TB and leishmaniasis

Dr Lisa Stockdale, University of Oxford, UK
Simon Waddell

Innovative tools to measure mycobacterial antigen expression in tissue

Dr Simon Waddell, University of Sussex, UK

Grant call round #3 - March 2019

Myron Christodoulides

Protective efficacy of conserved Leishmania hypothetical proteins against visceral leishmaniasis

Prof Myron Christodoulides, University of Southampton, UK
Rhea Coler

Development of an RNA based vaccine against Mycobacterium tuberculosis

Affiliate Prof Rhea Coler, Center for Global Infectious Disease Research, Seattle Children's Research Institute, USA
Francisco Javier Sánchez-Garcia

Metabolic reprogramming of skin microenvironment for improved BCG vaccine efficacy

Titular Prof Francisco Javier Sánchez-García, Instituto Politécnico Nacional, Mexico
Elena Stylianou

Developing a mouse model of diabetes to evaluate vaccines for TB and melioidosis

Dr Elena Stylianou, University of Oxford, UK
Julen Tomás Cortázar

Elucidating the T-cell epitopes and T-cells responses of two B. pseudomallei vaccine antigens

Dr Julen Tomás Cortázar, University College Dublin, Ireland

Monitoring and Addressing Challenging Risks, Rumours and Reputations Across the GCRF Vaccinology Networks

In 2018 three of the GCRF Vaccinology Networks, VALIDATE, HIC-VAC and IMPRINT, joined together to co-fund an 18-month long project based at the Vaccine Confidence ProjectTM at LSHTM. Read more below.

Heidi Larson

Vaccine Confidence Project

Prof Heidi Larson, LSHTM, UK

Grant call round #2 - June 2018

VALIDATE Member Photo

In vivo protection studies of chimeric Burkholderia pseudomallei antigens presenting multiple epitopes on protein scaffolds and outer membrane vesicles

Prof Gregory Bancroft, London School of Hygiene and Tropical Medicine (LSHTM), UK
Susanna Dunachie

Vaccines to target people with diabetes: characterising the pathways of immune response to M. tuberculosis and B. pseudomallei in people with diabetes compared to non-diabetics

Prof Susanna Dunachie, University of Oxford, UK
Mohamed Osman

Identification of Leishmania donovani and Mycobacterium tuberculosis- derived proteins on the surface of infected macrophages that are associated with ADCC induction

Dr Mohamed Osman, University of York, UK

Grant call round #1 - November 2017

Lucia Biffar

Natural variation of the bovine lymph node microenvironment and its possible effect on BCG immunogenicity

Dr Lucia Biffar, University of Oxford, UK
Delia Boccia

Enhancing BCG efficacy: the Social Technology Lab Initiative

Assist Prof Delia Boccia, London School of Hygiene and Tropical Medicine (LSHTM), UK
Panjaporn Chaichana

Establishment of a functional assay panel to evaluate the role of antibodies in defence against melioidosis and tuberculosis

Dr Panjaporn Chaichana, Mahidol-Oxford Tropical Medicine Research Unit, Thailand
Rajko Reljic

Overcoming innate immune tolerance in the respiratory tract for optimal vaccine design

Dr Rajko Reljic, St George's, University of London (SGUL), UK
Javier Salguero Bodes

The effect of BCG vaccination in immune responses against visceral leishmaniasis in a natural (canine) model of infection

Dr Javier Salguero Bodes, Public Heath England, UK
Steven Smith

How do functional and metabolic characteristics of trained monocytes affect their anti-bacterial activity?

Asst Prof Steven Smith, London School of Hygiene and Tropical Medicine (LSHTM), UK