Innovative tools to measure mycobacterial antigen expression in tissue
Led by Dr Simon Waddell (University of Sussex, UK), with Dr Javier Salguero Bodes (PHE, UK), Prof Gobena Ameni (Addis Ababa University, Ethiopia), Dr Sally Sharpe (PHE, UK) and Dr Ann Rawkins (PHE, UK)
Before we can hope to eradicate tuberculosis suffering worldwide, we need to identify the key protective antigens to target for vaccination that will eliminate Mycobacterium tuberculosis from the lung. This project will develop new RNA extraction and profiling techniques that will allow us to define the expression of M. tuberculosis (M.tb) antigens in lung tissue, at the site of disease. Our unique approach, building on international expertise from the UK and Ethiopia, will identify the key M.tb antigens for novel vaccine development, offering new opportunities for transformational change.