Weekly round-up #265
VALIDATE Seminar Spore-FP1 mucosal vaccine candidate for TB
Taking place at 15:00 BST, 4 July 2024
VALIDATE are excited to announce another upcoming online, this one focused on the development of a potential Spore-FP1 vaccine for tuberculosis (TB).
Prof Rajko Reljic will examine the Spore-FP1 mucosal vaccine candidate based on the fusion protein of Ag85B-Acr-HBHA/heparin-binding domain adsorbed on the surface of inactivated Bacillus subtilis spores. The vaccine candidate has shown significant protection in mice and guinea pigs when used as a mucosal boost to BCG, but did not improve the efficacy of BCG alone in NHP.
Mr Emil Vergara will then explore the potential of two subunit vaccine candidates, Spore-FP1 and Nano-FP1, as post-exposure TB vaccines in mice with pre-existing lung mycobacterial immunity elicited with Mycobacterium bovis BCG. The results have shown promising trends in the frequency of tissue-resident memory T cells, antigen-specific effector CD4 and CD8 T cells, and mucosal and systemic antibody responses among mice that received candidate vaccines.
Find out more and register - www.validate-network.org/event/sgul-seminar
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MRC Applied Global Health Partnership - This funding will develop an integrated research and innovation programme to deliver UK research capacity and capability – 15 July 2023
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NIH Global Infectious Disease Research Training Grants (GID) - program to address research training needs related to infectious diseases that are predominantly endemic in or impact upon people living in developing countries - deadline 3 August 2023
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Future Rural Africa: Female Researcher’s Grants - Grants is to promote female researchers at all stages of their careers- deadline 30 March 2024
Find a full list of all relevant external funding on our external funding page.
Training Opportunities and Events:
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ESACT Animal Cell Technology Course 2023, 13th edition, Llafranc, Costa Brava, Spain, 17 September 2023
Find more event opportunities on our Training and Events pages.
- Post-doctoral Research Assistant, Royal Veterinary College, Hertfordshire, UK, deadline 18 May 2023
- Associate or Senior Editor, Nature Immunology, New York, London, Heidelberg, Berlin, and Madrid- Hybrid working model, deadline 19 May 2023
Other relevant career opportunities are on our jobs page.
- A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice, VALIDATE Member Moagi Shaku et al, in bioRxiv
- Nature Opinion Article: Autophagy is part of the answer to tuberculosis, Vojo Deretic & Fulong Wang
Check out our Publications Page for members' publications and email VALIDATE@ndm.ox.ac.uk if you have a paper you would like us to include.
Highlights on Twitter this week:
The conflicts in Ukraine and Sudan have fuelled a surge in TB, Contemporary Pediatrics looked at the childhood vaccine pipeline (including BCG), and WHO published a bulletin on the TB Vaccine Challenge. There was a lot of discussion about the TB High Level meeting Multistakeholder meeting in New York using the #2023TBHLM hashtag. Nature reported on what it is like being a minority at a conference, racial inequalities in science journals, and how University of Oxford has banned relationships between staff and students.
Published: 10 May 2023
