Weekly round-up #265

SGUL Seminar

VALIDATE Seminar Spore-FP1 mucosal vaccine candidate for TB


Taking place at 15:00 BST, 4 July 2024

VALIDATE are excited to announce another upcoming online, this one focused on the development of a potential Spore-FP1 vaccine for tuberculosis (TB). 

Prof Rajko Reljic will examine the Spore-FP1 mucosal vaccine candidate based on the fusion protein of Ag85B-Acr-HBHA/heparin-binding domain adsorbed on the surface of inactivated Bacillus subtilis spores. The vaccine candidate has shown significant protection in mice and guinea pigs when used as a mucosal boost to BCG, but did not improve the efficacy of BCG alone in NHP.

Mr Emil Vergara will then explore the potential of two subunit vaccine candidates, Spore-FP1 and Nano-FP1, as post-exposure TB vaccines in mice with pre-existing lung mycobacterial immunity elicited with Mycobacterium bovis BCG. The results have shown promising trends in the frequency of tissue-resident memory T cells, antigen-specific effector CD4 and CD8 T cells, and mucosal and systemic antibody responses among mice that received candidate vaccines.

Find out more and register - www.validate-network.org/event/sgul-seminar



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Check out our Publications Page for members' publications and email VALIDATE@ndm.ox.ac.uk if you have a paper you would like us to include.


Highlights on Twitter this week:

The conflicts in Ukraine and Sudan have fuelled a surge in TB, Contemporary Pediatrics looked at the childhood vaccine pipeline (including BCG), and WHO published a bulletin on the TB Vaccine Challenge. There was a lot of discussion about the TB High Level meeting Multistakeholder meeting in New York using the #2023TBHLM hashtag. Nature reported on what it is like being a minority at a conference, racial inequalities in science journals, and how University of Oxford has banned relationships between staff and students.

Published: 10 May 2023