Objective
The purpose of this scheme is to provide funding for the best proposals to generate new knowledge about interventions that will contribute to the improvement of health in low and middle income countries. The scheme is focused on late-stage clinical and health intervention trials evaluating efficacy and effectiveness.
Proposal types
- Global health trial research grants
- Trial development grants
Priorities for this call
The scheme will give priority to proposals for definitive trials that are likely to produce implementable and generalisable results to change policy and practice. Trials should address the major causes of mortality or morbidity in low and middle income countries, particularly those that affect the most vulnerable populations. We are open to funding a smaller number of more ambitious trials than in previous years.
Applications must engage with the potential users of research for future implementation and impact for policy. Stakeholders, such as policy makers, should be engaged throughout the research process in order to ensure trial results are implementable, scalable and in line with policy needs. All applications must include investigators/partners based in the country/ies where the trial will take place.
Remit
Methodology
The joint global health trials scheme funds randomised controlled trials (RCTs), although nested studies and other types of methodologies can be used alongside RCTs to explore implementation and operational issues.
The scheme focuses on late-stage (equivalent to phase 3/4) clinical and health intervention trials that evaluate efficacy and effectiveness. We may consider Phase IIb trials of major relevance to the objectives of the call, but please contact the office to discuss this beforehand.
We encourage applications using adaptive trials designs and other innovative methodologies, where this is required to achieve the objectives of the evaluation. In all instances a clear justification for the chosen methodology must be provided and a clear reason for why the chosen trial design is likely to provide the most robust evidence to address the research question.
Intervention type
Although the breadth of the scheme is deliberately wide, we particularly welcome proposals for research addressing to the coexistence of two or more chronic conditions in the same individual as well as more broadly addressing chronic non- communicable diseases, including mental health, reproductive, maternal and new born health.
The scheme encourages the evaluation of a wide range of intervention types including, but not limited to:
- behavioural interventions
- psychological therapies
- disease management
- drugs
- vaccines
- hygiene interventions
- diagnostic strategies.
To find out more, or apply, visit the call webpage.