The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens
Post-doctoral position to work on COVID-19 - University of Geneva, 2020
Deadline for applications: 30 Apr 2020
In close collaboration with the virologists and clinicians at the Hospital in Geneva, the center of vaccinology is piloting a clinical study aimed at understanding the role of the immune response in the virological and clinical manifestations of COVID-19 in infected patients and their household contacts. A series of immunological read-outs, covering both innate and SARS-cov2-specific immune read-outs will be used to characterize the kinetics of the immune response in order to define correlates of risk of severe diseases or correlates of protection in those without symptoms.
The study is currently ongoing and we are urgently looking for a motivated and full time Post-doctoral fellow to contribute to the study, which will ultimately support the development of vaccine and therapeutics.
The position will be based in the Center of Vaccinology led by Prof Claire Anne-Siegrist and where Arnaud Didierlaurent has been recently appointed as assistant Professor. The candidate is expected to work closely with clinicians at the hospital and will also benefit from the multicultural and trans-disciplinary environment offered by the faculty of medicine
The postdoctoral fellow will be responsible for the development and implementation of functional antibody assays (FcR binding, innate cell activation..) and the analysis of the transcriptional signature in blood (RNAseq). The fellow will also be involved in the in-depth characterization of SARS-Cov2 -specific T and B cell response (including single cell RNAseq analysis). The candidate is expected to work closely with the bio-informatician in the laboratory on data analysis as well as on the integration of the immunological data with the clinical and virological parameters measured in the study. The University of Geneva offers access to cutting-edge technical platforms, including flow cytometry and genomics.
Applicants should hold a PhD in immunology or related field (e.g. innate immunity, vaccinology) and should have a solid research background in human immunology. Technical expertise with flow cytometry (e.g. setting up of complex marker panels), primary human cell culture and immune monitoring is expected. Additional experience in system biology approaches, including multidimensional data integration, would be an advantage.
As soon as possible, the targeted date being June 1st, 2020.
For more information, or to apply, visit the job webpage.