The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens
Research Fellow, University of Edinburgh, UK, Jul 2018
Employer: University of Edinburgh, UK
We are looking for an enthusiastic, motivated researcher with experience in cellular and molecular immunology and/or vaccinology to join the group led by Professor Jayne Hope at The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh. The position is funded by the Biotechnology and Biological Research Council (BBSRC) to study the mechanisms of vaccine-induced protective immunity to a range of important cattle diseases including bovine tuberculosis and East Coast fever. The role will involve characterising cells that have been isolated from vaccine draining sites in vivo using a unique surgical cannulation model, and will require significant skills in immunological assays including cell isolation, flow cytometry and in qPCR/RNA sequencing. The project will deliver signatures of protective immunity that will influence vaccine design in the future. This is a multidisciplinary project which will be undertaken by a research team includes a bioinformatician and a part-time research assistant.
You should have a PhD, or be nearing completion of a PhD, with substantial expertise in cellular and molecular immunology including flow cytometry, quantitative PCR and cell isolation/culture techniques. Experience of working in veterinary immunology or vaccinology would be desirable, but is not essential. Excellent communication skills and the ability to work as part of a team are essential for this project.
This post is for 2.5 years and is available immediately. The post holder will be part of the Division of Infection and Immunity at The Roslin Institute which has a very active and supportive research environment.
Informal enquiries to discuss the post are encouraged and can be addressed to Prof Jayne Hope (firstname.lastname@example.org) in confidence. Please include ‘VACCINE’ in the subject line for such enquiries.
To perform cellular and molecular analyses to determine immune signatures associated with protective vaccine responses as part of a BBSRC funded project. The project uses a novel technique to capture cells draining from vaccination sites and will compare protective and non-protective vaccines to define correlates of immune protection against important cattle pathogens. Detailed immunological and molecular analyses will be undertaken.
For further details and to apply for this role, visit the job vacancy webpage (ref 044362).