Gyeongsang University College of Medicine, South Korea
TB, animal models, correlates of protection, novel TB vaccines
Our research is mainly focused on the development of improved multi-antigenic subunit vaccines by identifying novel antigens from Mtb clinical strains and employing adjuvant combinations as prophylactics or BCG-primed boosted regimens in murine models. Based on the vaccine efficacy, identifying immunological protective correlates are also our research interest. In addition, we also focused on underlying mechanisms of TB reactivation or susceptibility to recent infection during immunosuppressive drug therapy.
Weblinks of interest
- Choi HG, Kwon KW, Choi S, Back YW, Park HS, Kang SM, et al. (2020). Antigen-Specific IFN-WIL-17-Co-Producing CD4(+) T-Cells Are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine. Vaccines (Basel) 8.
- Kwon KW, Lee A, Larsen SE, Baldwin SL, Coler RN, Reed SG, et al. (2019c). Long-term protective efficacy with a BCG-prime 1D93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model. Sci Rep 9: 15560.
- Choi HH, Kwon KW, Han SJ, Kang SM, Choi E, Kim A, et al. (2019). PPE39 of the Mycobacterium tuberculosis strain Beijing/K induces Th1- cell polarization through dendritic cell maturation. J Cell Sci 132.
- Kwon KW, Choi HH, Han SJ, Kim IS, Kim WS, Kim H, et al. (2019a). Vaccine efficacy of a Mycobacterium tuberculosis Beijing-specific proline-glutamic acid (PE) antigen against highly virulent outbreak isolates. Faseb j 33: 6483-6496.