Bernardo Villarreal-Ramos

Bernardo Villarreal-Ramos

Professor of Immunology

University of Aberystwyth, UK







Network Management Board member 2018+, Network Investigator


Research Keywords: 

TB, Animal Models, Vaccines, T-cells



I am a cellular immunologist with over 30 years experience in infection and immunity. I have worked on the immune response to mycobacteria in cattle since 2000. I am currently leading research on the immune response to mycobacteria with the aim of developing improved vaccines and diagnostics. Particular interests include the elucidation of the components of the adaptive immune response that contribute to the detection of cattle infected with mycobacteria and identification of potentially novel immune response signatures that would permit the identification of cattle infected in farms. I have authored over 90 scientific publications. I have been PI and co-applicant in projects funded by the BBSRC and DEFRA. I am a member of the editorial board of the journal TBED. I have acted as a referee for funders such as the BBSRC, Wellcome Trust, WOTRO etc.I have also acted as an examiner for MSc and PhD candidates.


Key Publications:

Vordermeier,,H.M., Jones, G.J., Buddle, B.M., Hewinson, R.G. and Villarreal-Ramos, B. (2016) Bovine Tuberculosis in Cattle: Vaccines, DIVA Tests, and Host Biomarker Annual Review of Animal Biosciences; 4 (4): 87-109. DOI: 10.1146/annurev-animal-021815-111311.

Salguero, F. J., Gibson, S., Garcia-Jimenez, W., Gough, J., Strickland, T. S., Vordermeier, H. M. and Villarreal-Ramos, B. (2016) Differential Cell Composition and Cytokine Expression Within Lymph Node Granulomas from BCG-Vaccinated and Non-vaccinated Cattle Experimentally Infected with Mycobacterium bovis. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12561.

Metcalfe, H. J., Steinbach, S., Jones, Gareth J., Connelley, T., Morrison, W.I., Vordermeier, M. and Villarreal-Ramos, B. (2016). Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A. Vaccine; 34 (38): 4520-5. DOI: 10.1016/j.vaccine.2016.07.055.

Blunt, L., Hogarth, P. J., Kaveh, D. A., Webb, P., Villarreal-Ramos, B. and Vordermeier H.M. (2015) Phenotypic characterization of bovine memory cells responding to mycobacteria in IFN gamma enzyme linked immunospot assays. Vaccine; 33 (51): 7276-7282 DOI: 10.1016/j.vaccine.2015.10.113.

Gillian, D. S., Clifford, D., Whelan, A. O. Tchilian, E. Z., Beverley, P.C., Salguero, F.J., Xing, Z., Vordermeier, H. M. and Villarreal-Ramos, B. (2015) Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle. PLoS One; 10 (11). DOI: 10.1371/journal.pone.0142270.