Caleb Nwongbouwoh Muefong

Caleb Nwongbouwoh Muefong

Postdoctoral Research Associate

University of Chicago







Network Associate


Research Keywords:

TB, Innate Immunity, Neutrophils



I joined Khader lab in 2021 as Postdoc Research Associate. My PhD (Ludwig Maximilian University of Munich, Germany/ MRC Unit The Gambia at London School of Hygiene and Tropical Medicine) aimed at investigating the contribution of neutrophil phenotypes and function on the severity of chronic TB-induced lung impairment and recovery post-treatment in humans. I previously obtained an MSc in Biochemistry at the University of Yaounde I, Cameroon and an MSc by Research in Biomedical Sciences at The University of Edinburgh, UK. At the Khader lab, I focus on the impact of TB-induced innate immune responses on Mtb control, TB severity and lung pathology.


Related Websites:

University of Chicago




Key Publications:

  • Auld SC, Muefong C, Barczak A, Pooran A, Coussens A, Mitini-Nkhoma S, Tezera L, Steyn A, Bishai W, Naidoo T, Dewi I, Walker NF. Pathogenesis of Post-TB Lung Disease: Defining Knowledge Gaps and Research Priorities. AJRCCM. 2024; Manuscript submitted.
  • Goletti, Delia; Aiello, Alessandra; Tientcheu, Leopold; Muefong, Caleb; Hu, Ting Huey; Niewold, Paula; Joosten, Simone; Ong, Catherine; Sutherland, Jayne. Host-pathogen interactions in the context of tuberculosis infection and disease. ERS. 2023. 101: Tuberculosis.
  • C. Muefong, O. Owolabi, B. Amadou, A. Rachow, C. Geldmacher, S. Khader, J. Sutherland. Innate Mtb susceptibility is driven by CD177 (Ly6G) upregulation and TB progression is sustained via PD-L1—mediated immunosuppressive function of infiltrating Ly6G+PMNs. Manuscript under preparation.
  • Jobe D, Darboe F, Muefong CN, Barry A, Coker EG, Mohammed N, Jobe A, Davies MM, Faye B, Jallow R, Donkor S, Touray S, Owolabi O, Sutherland JS. Gene expression in TB disease measured from the periphery is different from the site of infection.Tuberculosis (Edinb). 2022 Mar 17;134:102187. doi: 10.1016/ Epub ahead of print. PMID: 35316743.
  • Caleb Nwongbouwoh Muefong, Olumuyiwa Owolabi, Simon Donkor, Salome Charalambous, Joseph Mendy, Isatou C M Sey, Abhishek Bakuli, Andrea Rachow, Christof Geldmacher, Jayne S. Sutherland. Major neutrophil-derived soluble mediators associate with baseline lung pathology and post-treatment recovery in tuberculosis patients. Front Immunol. 2021; 12:740933.
  • Caleb Nwongbouwoh Muefong, Olumuyiwa Owolabi, Simon Donkor, Salome Charalambous, Abhishek Bakuli, Andrea Rachow, Christof Geldmacher, Jayne S. Sutherland. Neutrophils contribute to severity of tuberculosis pathology and recovery from lung damage pre- and post-treatment. Clin Infect Dis. 2021:ciab729. doi: 10.1093/cid/ciab729. PMID: 34427644. 
  • Molly A. Vickers, Fatoumatta Darboe, Caleb N. Muefong, Georgetta Mbayo, Amadou Barry, Awa Gindeh, Sainabou Njie, Abi-Janet Riley, Binta Sarr, Basil Sambou, Hazel M. Dockrell, Salome Charalambous, Andrea Rachow, Olumuyiwa Owolabi, Shamanthi Jayasooriya and Jayne S. Sutherland. Monitoring Anti-tuberculosis Treatment Response Using Analysis of Whole Blood Mycobacterium tuberculosis Specific T Cell Activation and Functional Markers. Front Immunol. 2020; 11:572620.
  • Muefong CN, Sutherland JS. Neutrophils in Tuberculosis-Associated Inflammation and Lung Pathology. Front Immunol. 2020; 11:962. doi: 10.3389/fimmu.2020.00962. PMID: 32536917; PMCID: PMC7266980.