Charles Gauthier

Charles Gauthier


Institut National de Ia Recherche Scientifique (INRS), Canada







Network Investigator


Research Keywords:

Carbohydrate Chemistry, Glycoconjugate Vaccines, Burkholderia pseudomallei, Burkholderia mallei, Melioidosis, Glanders



Dr. Charles Gauthier earned his PhD in natural products chemistry from the Université du Québec à Chicoutimi (UQAC), followed by postdoctoral fellowships in carbohydrate chemistry at the Institut Pasteur in Paris and in chemobiology at the University of Oxford in United Kingdom. After a five-year tenure as a Senior Lecturer at the University of Poitiers in France, Dr. Gauthier joined the Centre Armand-Frappier Santé Biotechnologie of the Institut national de la recherche scientifique (INRS) in 2016 and was promoted to Full Professor in 2023. Since 2022, he has served as the co-director of the Unité mixte de recherche (UMR) INRS-UQAC.

Dr. Gauthier’s research program centers on the synthesis of microbial glycans for the development of prophylactic and therapeutic approaches. He has published >60 peer-reviewed papers and book chapters and supervised the work of >55 students, trainees, and postdocs. Dr. Gauthier’s research program has received funding from various granting agencies, including NSERC, CIHR, Pasteur Network, and NIH. Notably, Dr. Gauthier has been a recipient of FRQS salary support as both Junior 2 and Senior Scholar. Actively engaged in the academic community, Dr. Gauthier is a member of several national and international learned societies, including Oxford University’s VALIDATE network, GlycoNet, CRIPA, RISUQ, CISD, and CERMO-FC.


Related Websites:



The Gauthier Group

Institut National de Ia Recherche Scientifique (INRS)


Key Publications:

  • Manmode, S.; Hussain, N.; Gamboa Marin, O. J.; Kato, A.; Veytia-Bucheli, J. I.; Vincent, S. P.; Gauthier, C.* Thioarylation of 6-amino-2,3,6-trideoxy-D-manno-oct-2-ulosonic acid (iminoKdo): access to 3,6-disubstituted picolinates and mechanistic insights. Chem. Eur. J. 2024, 30, e202303904 (invited contribution)
  • Cloutier, M.; Lavoie, S.; Gauthier, C.* C7 epimerization of benzylidene-protected β-D-idopyranosides brings structural insights into idose conformational flexibility. J. Org. Chem. 2022, 87, 12932-12953
  • Muru, K.; Cloutier, M.; Provost-Savard, A.; Di Cintio, S.; Burton, O.; Cordeil, J.; Groleau, M.-C.; Legault, J.; Déziel, E.; Gauthier, C.* Total synthesis of a chimeric glycolipid bearing the partially acetylated backbone of sponge-derived agminoside E. J. Org. Chem. 2021, 21, 15357-15375
  • Cloutier, M.; Prévost, M.-J.; Lavoie, S.; Feroldi, T.; Piochon, M.; Groleau, M.-C.; Legault, J.; Villaume, S.; Crouzet, J.; Dorey, S.; De Rienzo, M. A. D.; Déziel, E.; Gauthier, C.* Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids. Chem. Sci. 2021, 12, 7533-7546
  • Muru, K.; Gauthier, C.* Glycosylation and protecting group strategies towards the synthesis of saponins and bacterial oligosaccharides: a personal account. Chem. Rec. 2021, 11, 2990-3004 (invited contribution for the special issue on "Recent advances in carbohydrate chemistry")
  • Cloutier, M.; Gauthier, C.* Progress towards the development of glycan-based vaccines against campylobacteriosis. ACS Infect. Dis. 2021, 7, 969-986 (invited contribution for the special issue on "Gut pathogens")
  • Cloutier, M.; Delar, E.; Muru, K.; Ndong, S.; Hoyeck, R. R.; Kaewarpai, T.; Chantratita, N.; Burtnick, M. N.; Brett, P. J.; Gauthier, C.* Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens. Org. Biomol. Chem. 2019, 17, 8878-8901 (invited contribution for the web themed issue on "Glycosylation: New methodologies and applications")
  • Cloutier, M.; Muru, K.; Ravicoularamin, G.; Gauthier, C.* Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis. Nat. Prod. Rep. 2018, 35, 1251-1293
  • Tamigney Kenfack, M.; Mazur, M.; Nualnoi, T.; Shaffer, T. L.; Ngassimou, A.; Blériot, Y.; Marrot, J.; Marchetti, R.; Sintiprungrat, K.; Chantratita, N.; Silipo, A.; Molinaro, A.; AuCoin, D. P.; Burtnick, M. N.; Brett, P. J.; Gauthier, C.* Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. Nat. Commun. 2017, 8, 115
  • Marchetti, R.; Dillon, M. J.; Burtnick, M. N.; Hubbard, M. A.; Tamigney Kenfack, M.; Blériot, Y.; Gauthier, C.; Brett, P. J.; AuCoin, D. P.; Lanzetta, R.; Silipo, A.; Molinaro, A. Burkholderia pseudomallei capsular polysaccharide recognition by a monoclonal antibody reveals key details toward a biodefense vaccine and diagnostics against melioidosis. ACS Chem. Biol. 2015, 10, 2295-2302