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Senior Research Fellow / PhD student
Institute of Post-Graduate Medical Education and Research (IPGMER), India
Email: deblinasarkar09@gmail.com
VALIDATE Role:
Network Affiliate
Research Keywords:
Leishmaniasis, Chemotherapeutics, Endoperoxides, Immunometabolism
Biography:
My research work is focused on studying the redox and metabolic status of Leishmania parasites, the causative agent of Leishmaniasis, a neglected tropical disease, with 8% of global burden being contributed by India. My work has led to the identification of promising antileishmanial compounds that mediate their leishmanicidal activity by impacting on mitochondrial and/or glycolytic bioenergetics of Leishmania parasites that can potentially serve as a vital resource to underpin future mechanistic studies for developing new chemotherapeutic molecules.
Related websites:
LinkedIn Profile
ResearchGate Profile
Key Publications
- Roy M, Ceruti A, Kobialka RM, Roy S, Sarkar D, Wahed AAE, Chatterjee M. Evaluation of Recombinase Polymerase Amplification assay for monitoring parasite load in patients with kala-azar and post kala-azar dermal leishmaniasis. PLoS Negl Trop Dis. 2023;17:e0011231. doi:10.1371/journal.pntd.0011231.
- Sarkar D, De Sarkar S, Gille L, Chatterjee M. Ascaridole exerts the leishmanicidal activity by inhibiting parasite glycolysis. Phytomedicine. 2022; 103:154221. doi: 10.1016/j.phymed.2022.154221.
- Roy M, Sarkar D, Chatterjee M. Quantitative monitoring of experimental and human leishmaniasis employing amastigote- specific genes. Parasitology. 2022; 149:1085-1093. doi: 10.1017/S0031182022000610.
- Ramesh D, Sarkar D, Joji A, Singh M, Mohanty AK, Vijayakumar BG, Chatterjee M, Sriram D, Muthuvel SK, Kannan T. Erratum: First-in-class pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones against leishmaniasis and tuberculosis: Rationale, in vitro, ex vivo studies and mechanistic insights. Arch Pharm (Weinheim). 2022; 355:e2100440. doi: 10.1002/ardp.202100440. Erratum in: Arch Pharm (Weinheim). 2022; 355:e2270007. doi: 10.1002/ardp.202270007.
- De Sarkar S*, Sarkar D*, Sarkar A, Dighal A, Staniek K, Gille L, Chatterjee M. Berberine chloride mediates its antileishmanial activity by inhibiting Leishmania mitochondria. Parasitol Res. 2019; 118:335-345. doi: 10.1007/s00436-018-6157-3. (*Joint first author)
- De Sarkar S, Sarkar D, Sarkar A, Dighal A, Chakrabarti S, Staniek K, Gille L, Chatterjee M. The leishmanicidal activity of artemisinin is mediated by cleavage of the endoperoxide bridge and mitochondrial dysfunction. Parasitology. 2019; 146:511-520. doi: 10.1017/S003118201800183X.
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