Dylan Sheerin

Walter and Eliza Hall Institute of Medical Research (WEHI), Australia

VALIDATE Role: Network Investigator

Research Keywords: TB; transcriptomics; single-cell; bioinformatics; host-pathogen; RNA-seq

Biography:

Dylan made the move to Melbourne, Australia in 2020 to join Anna Coussens’ lab at WEHI where he has been applying his expertise to the next-generation sequencing analysis to advance understanding of what constitutes protection against Mycobacterium tuberculosis and the immunological changes that underpin tuberculosis disease progression and the environmental and host factors influencing susceptibility to and loss of control of Mtb infection. Dylan also has expertise in the generation and analysis of bulk and single-cell RNA-sequencing and spatial transcriptomic data arising from human whole blood and tissue samples.

His current research includes work attributing of whole blood transcriptional changes to parenchymal abnormalities associated with subclinical tuberculosis detected by PET/CT imaging of household contacts in Khayelitsha and the analysis of single-cell RNA-seq data captured from whole blood samples, subjected to ex vivo Mtb infection, from schoolchildren in Cape Town.

Key Publications:

Issues in vaccinology: Present challenges and future directions.
Sheerin D, Openshaw PJ, Pollard AJ. Eur J Immunol. 2017
Dec;47(12):2017-2025. doi: 10.1002/eji.201746942. Epub 2017 Sep 27.
Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.
O'Connor D, Pinto MV, Sheerin D, Tomic A, Drury RE, Channon-Wells S, Galal U, Dold C, Robinson H, Kerridge S, Plested E, Hughes H, Stockdale L, Sadarangani M, Snape MD, Rollier CS, Levin M, Pollard AJ. Mol Syst Biol. 2020 Nov;16(11):e9888. doi: 10.15252/msb.20209888.
Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen. Sheerin D, Dold C, O'Connor D, Pollard AJ, Rollier CS. BMC Genomics.
2021 Oct 30;22(1):777. doi: 10.1186/s12864-021-08061-8. Immunopathogenic overlap between COVID -19 and tuberculosis identified from transcriptomic meta -analysis and human macrophage infection. Sheerin D, Abhimanyu, Peton N, Vo W, Allison CC, Wang X, Johnson WE, Coussens AK. iScience. 2022 May 25;25(6):104464. doi: 10.1016/j.isci.2022.104464. eCollection 2022 Jun 17.