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Researcher
Pasteur Institute of Iran, Iran
Email: elham_gholami@yahoo.com
VALIDATE Role:
Network Associate
Research Keywords:
Leishmaniasis, Vaccine and Immunotherapy, Animal Model, Sand Fly Salivary Components, Vector Biomarker Exposure
Biography:
Elham has been working in the Immunotherapy and Leishmania Vaccine Research Department at the Pasteur Institute of Iran since 2007. Her main area of research has been on Leishmaniasis causing health problems within her home country of Iran. Specifically, she has focused on the design of DNA and live vaccines against leishmaniasis targeting Leishmania antigens. In addition, she has dedicated over nine years to studying the salivary components of leishmanial vectors for their potential as a vaccine candidate. Recently, she has investigated their utility as biomarkers of sand fly exposure too. Throughout her professional journey, Elham has co-authored over 24 scientific publications and has effectively mentored numerous PhD and MSc students, providing valuable guidance to complete their theses.
Related Websites:
LinkedIn
Google Scholar
Key Publications:
- Lajevardi MS, Gholami E, Taheri T, Sarvnaz H, Habibzadeh S, Seyed N, Mortazavi Y and Rafati S. Leishmania tarentolae as Potential Live Vaccine Co-Expressing Distinct Salivary Gland Proteins Against Experimental Cutaneous Leishmaniasis in BALB/c Mice Model. Front. Immunol. 2022 June 13:895234
- Gholami E, Oliveira F, Taheri T, Seyed N, Gharibzadeh S, Gholami N, Mizbani A, Zali F, Habibzadeh S, Bakhadj DO, Meneses C, Kamyab-Hesari K, Sadeghipour A, Taslimi Y, Khadir F, Kamhawi S, Mazlomi MA, Valenzuela JG, Rafati S. DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica. PLoS Negl Trop Dis. 2019 Jan 11;13(1)
- Gholami E, Zahedifard F, Rafati S. Delivery systems for Leishmania vaccine development. Expert Rev Vaccines. 2016 Mar 28:1-17
- Zahedifard F*, Gholami E*, Taheri T, Taslimi Y, Doustdari F, Seyed N, Torkashvand F, Meneses C, Papadopoulou B, Kamhawi S, Valenzuela JG, Rafati S. Enhanced protective efficacy of nonpathogenic recombinant leishmania tarentolae expressing cysteine proteinases combined with a sand fly salivary antigen. PLoS Negl Trop Dis. 2014 Mar 27; 8(3):e2751. (*Co-first author)
- Rafati S, Gholami E, Hassani N, Ghaemimanesh F, Taslimi Y, Taheri T, Soong L. Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients. Vaccine. 2007 May 22; 25(21):4159-69
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