Fatoumatta Darboe

Fatoumatta Darboe

Postdoctoral Researcher

University of California San Fransisco (UCSF), USA

Email: fatoumatta.darboe@ucsf.edu






Network Associate


Research Keywords: 

TB, Biomarkers, HIV



I am an Assistant Professional researcher in the Division of Experimental Medicine (DEM) at the UCSF. The main aim of my research is the definition of correlates of risk and protection from tuberculosis (TB) disease and comorbidities specifically, HIV, following exposure to inform vaccine design and host-directed therapies. I was a postdoctoral scholar at the MRCG at LSHTM leading projects determining the effect of TB disease on long term lung health. During my PhD, I worked on several multi-site consortia to define TB correlates of disease risk in several South African cohorts of individuals co-infected with Mycobacterium tuberculosis (Mtb) and Human Immunodeficiency Virus (HIV), which led to the validation and publication of several blood-based transcriptional biomarkers of risk, including an 11-gene biomarker (Darboe11), which predicted and diagnosed TB disease, and predicted treatment responses in several TB/HIV co-infected cohorts.


Key Publications:

Fatoumatta Darboe, Mbandi S Kimbung, Kogieleum Naidoo et al. Detection of Tuberculosis recurrence, Diagnosis and Treatment response by a blood transcriptomic signature in HIVinfected persons on antiretroviral therapy. Frontiers in Microbiology, June 2019, 10; doi:10.3389/fmicb.2019.01441

Roshni Roy Chowdhury, Francesco Vallania, Cesar Joel Lopez Angel et al. A multi-cohort study of the immune factors associated with M tuberculosis infection outcomes. Nature 560, 7720, 664648 (2018), doi:10.1038/s41586-018-0439-x

Fatoumatta Darboe, Mbandi S Kimbung, Ethan Thompson et al. Tuberculosis (Edinb). 2018 Jan;108:124-126. doi:10.1016/j.tube.2017.11.001.  

Fatoumatta Darboe, Jane U Adetifa, John Reynolds et al. Frontiers in immunology 2017 Sep 8;8:1092. doi: 10.3389/fimmu.2017.01092.  

Thomas J. Scriba, Adam Penn-Nicholson, Smitha Shankar et al. Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease. Plos pathogens, 13 (11):e1006687 https://doi.org/10.1371/journal. ppat.1006687

Patrizia Amelio, Damien Portevin, Klaus Reither et al. Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell Responses in Patients with Active Pulmonary Tuberculosis from Tanzania. Plos Negl Trop Dis. 2017 Jul 31;11(7):e0005817. doi: 10.1371/journal.pntd.0005817.  

Suraj P. Parihar, Mumin Ozturk, Mohlopheni J. Marakalala et al. Protein Kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. Mucosal Immunology, 2017 Aug 23. doi: 10.1038/mi.2017.68.  

Fletcher HA, Snowden MA, Landry B, Rida W et al. T-cell activation is an immune correlate of risk in BCG vaccinated infants. Nat Commun. 2016 Apr 12;7:11290. doi: 10.1038/ncomms11290.

Muhammed O. Afolabi, Jorjoh Ndure, Abdoulie Drammeh et al. A Phase I Randomized Clinical Trial of Candidate Human Immunodeficiency Virus type 1 Vaccine MVA.HIVA Administered to Gambian Infants. PloS one, 8(10), e78289. doi:10.1371/journal.pone.0078289

Alba Llibre, Nicole Bilek, Vincent Bondet, et al. Plasma Type I IFN protein concentrations in human tuberculosis (manuscript under review).