Head of the Department of Clinical Vaccine Research
International Tuberculosis Research Centre, South Korea
Tel: 82 10 3296 9805
TB, biomarker, correlates of risk, correlates of protection, novel TB vaccine clinical trials
Our research of interest is mainly focused on evaluation of novel vaccine candidates against tuberculosis and immunologic diagnosis tools of latent tuberculosis infection and active tuberculosis. Based on collaborations with national and international organizations, we have actively involved in a number of studies in different populations of S. Korea, such as BCG vaccinated children, adolescents with LTBI, active tuberculosis patients, and healthy adults.
Leem AY, Song JH, Lee EH, Lee H, Sim B, Kim SY, Chung KS, Kim EY, Jung JY, Park MS, et al. Changes in cytokine responses to TB antigens ESAT-6, CFP-10 and TB 7.7 and inflammatory markers in peripheral blood during therapy. Sci Rep. 2018 Jan 18;8(1):1159.
Song Yee Kim, Jungho Kim, Deok Ryun Kim, Young Ae Kang, Sungyoung Bong, Jonghee Lee, Su-Yeon Kim, Nam Suk Lee, Bora Sim, Sang Nae cho, Young Sam Kim, Hyejon Lee. Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis. Submitted to BMC infectious disease. 2018. Under review.
Lee HJ, Choi HJ, Kim DR, Lee H, Jin JE, Kim YR, Lee MS, Cho SN and Kang YA, Safety and Efficacy of Tuberculin Skin Testing with Microneedle MicronJet600TM in Healthy Adults. INT J TUBERC LUNG DIS 20(4):500–504.
Jeong YH, Hur YG, Lee H, Kim S, Cho JE, Chang J, Shin SJ, Lee H, Kang YA, Cho SN, et al. Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production. J Clin Microbiol. 2015 Feb;53(2):504-10.
Kim SH, Lee HJ, Kim HJ, Kim YE, Cho JE, Jin HW, Kim DY, Ha SJ, Kang YA, Cho,SN and Lee HY. Diagnostic Performance of a Cytokine and IFN-g induced Chemokine mRNA Assay after Mycobacterium tuberculosis Specific Antigen Stimulation in Whole Blood from Infected Individuals. J Mol Diagn. 2015. Jan; 17(1):90-9
Hong JY, Lee HJ, Kim SY, Chung KS, Kim EY, Jung JY, Park MS, Kim YS, Kim SK, Chang J, et al. Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. J Infect. 2014 Mar;68(3):252-8.
Kim, S., Cho, J. E., Kim, H., Lee, D., Jeon, B. Y., Lee, H., ... & Lee, H. (2013). Comparison of Mycobacterium tuberculosis Specific Antigen Stimulation Time for Performing Interferon Gamma mRNA Assay for Detecting Latent Tuberculosis Infection. The Korean Society For Biomedical Laboratory Sciences, 19(2), 90-97. 8) Hong JY, Jung GS, Kim H, Kim YM, Lee HJ, Cho SN, Kim SK, Chang J, Kang YA. Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis. International Journal of Infectious Diseases. 2012 Dec;16(12):e855-9
S. Y. Kim, M. S. Park, Y. S. Kim, S. K. Kim, J. Chang, H. J. Lee, S.-N. Cho & Y. A. Kang. The Responses of Multiple Cytokines Following Incubation of Whole Blood from TB Patients, Latently Infected Individuals and Controls with the TB Antigens ESAT-6, CFP-10 and TB7.7. Scandinavian Journal of Immunology, 2012 Dec; 76(6):580-6
Kim, S., Kim, Y. K., Lee, H., Cho, J. E., Kim, H. Y., Uh, Y., ... & Lee, H. (2012). Interferon gamma mRNA quantitative real-time polymerase chain reaction for the diagnosis of latent tuberculosis: a novel interferon gamma release assay. Diagnostic microbiology and infectious disease.
Lee H, Dockrell HM, Kim DR, Floyd S, Oh SY, Lee JB, Kim HJ. The Current Status of BCG Vaccination in Young Children in South Korea. Tuberc Respir Dis (Seoul). 2012 Apr;72(4):374-80. doi: 10.4046/trd.2012.72.4.374. Epub 2012 Apr 30. PubMed PMID: 23227079; PubMed Central PMCID: PMC3510289. 12) Lee H, Cho SN, Kim HJ, Anh YM, Choi JE, Kim CH, Ock PJ, Oh SH, Kim DR, Floyd S, Dockrell HM. Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea. Vaccine. 2011 Sep 2; 29(38):6564-71.