Jelkeba Bali Weyesa

My main areas of interest are currently researching on the genomics of Mycobacterium tuberculosis complex by using Whole genome sequencing and different bioinformatic analyses but broadly, further relevant topics focusing on infectious diseases may also be considered. The current gain of deeper insights into the genomics of Mycobacterium tuberculosis complex have largely impacted on in-depth understanding of their transmission dynamicity, genetic diversity, the evolution of multidrug resistant strains, the rate of resistance mutations, phylogenetic properties, designing curative regimes (identifying potential therapeutic candidates), and eventually its control programs. Because DNA sequencing-based tools revolutionized our understanding of the genomics of infectious diseases; calling genetic variations at nucleotide level, identifying arrays of virulent genes, and so thus provides higher resolution than other common typing methods.

There has been mounting evidence that evolutionary properties of clinical isolates highly influence their pathogenicity, effectiveness of therapeutic measures, and prognosis of all forms of tuberculosis. This emergence of various mutations in mycobacterial nucleic acids is one of the major factors underlying those evolution, providing the working materials for their natural selections. Many of these gene mutations observed can serve as phylogenetic markers for strain classification while others encode deadly drug resistant mutations to all existing treatment options. The different strain family of Mycobacterium tuberculosis complex (MTBC) has also gained considerable attention because of its strong association with drug resistances.

Weyesa JB. Seroprevalence of Typhoid Fever among Subjects with Acute Febrile Manifestations at Tertiary Care Center, Addis Ababa, Ethiopia. International Journal of Science and Research (IJSR). 2014 October; 3(10):147-155.

Weyesa JB. Concurrent Infections and Louse-Flea Borne Typhus Fever in Acute Febrile Patients Diagnosed Serologically In International Clinical Laboratories, Addis Ababa, Ethiopia. International Journal of Science and Research (IJSR). 2014 October; 3(10):289-296.

Weyesa JB, Taddesse AH, Eba TY, Minta MK, Gudu HT, Mehirte YT. Prevalence and Risk Factors Associated with Maternal Mortality in Mizan-Aman Hospital, Bench Maji, Southwest Ethiopia. Women’s Health Care. 2015 November; 4(6):272. doi: 10.4172/2167-0420.1000274.

Tadesse AH, Weyesa JB. Maternal and Child Health Survey in Kometa Sub-locality, Mizan-Aman Town, Southwest Ethiopia. Journal of Community Medicine & Health Education. 2015 October; 5(5):372. doi: 10.4172/2161-0711.1000372.

Tadesse AH, Weyesa JB. Community Based Socio-Demographic and Environmental Health Survey in Kometa Sub-locality, Mizan-Aman Town, Bench Maji Zone, Southwest Ethiopia. Journal of Community Medicine & Health Education. 2015 August; 5(4):365. doi: 10.4172/2161-0711.1000365.

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