Jérôme Nigou

CNRS Research Director

University of Toulouse, France

Tel: + 33 (0)5 61 17 55 04

VALIDATE Role:

Network Investigator

Research Keywords:

Tuberculosis; cellular and animal models; host/pathogen interaction; innate immunity; mycobacterial lipids and glycoconjugates; structure/function relationships

Biography:

Mymain objectives are to decipher the molecular cross-talk that establishes during infection between Mycobacterium tuberculosis and host innate immune cells, with a special focus on the role played by lipids and glycoconjugates. I also aim at translating these fundamental data into new therapeutic or preventive strategies/tools to be explored.

Related Websites:

IPBS website

Key Publications:

Blanc, L., Gilleron, M., Prandi, J., Song, O.-R., Jang, M.-S., Gicquel, B., Drocourt, D., Neyrolles, O., Brodin, P., Tiraby, G., Vercellone, A. & Nigou, J. (2017) Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. Proc Natl Acad Sci USA, 114(42):11205-11210.

Decout, A., Silva-Gomes, S., Drocourt, D., Barbe, S., André, I., Cueto, F.J., Lioux, T., Sancho, D., Pérouzel, E., Vercellone, A., Prandi, J., Gilleron, M., Tiraby, G. & Nigou, J. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. Proc Natl Acad Sci USA, 114(10), 2675-2680.

Vergne, I., Gilleron, M. & Nigou, J. (2015) Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan. Front Cell Infect Microbiol, 4, 187.

Vétizou, M., Pitt, J.M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M.P., Duong, C.P.M., Poirier-Colame, V., Roux, A., Becharef, S., Formenti, S., Golden, E., Cording, S., Eberl, G., Schlitzer, A., Ginhoux, F., Mani, S., Yamazaki, T., Jacquelot, N., Enot, D.P., Bérard, M., Nigou, J., Opolon, P., Eggermont, A., Woerther, P.L., Chachaty, E., Chaput, N., Robert, C., Mateus, C., Kroemer, G., Raoult, D., Gomperts Boneca, I., Carbonnel, F., Chamaillard, M. & Zitvogel, L. (2015) Anticancer immunotherapy by CTLA4 blockade relies on the gutmicrobiota. Science, 350(6264), 1079-84.

Blattes, E., Vercellone, A., Eutamène, H., Turrin, C.O., Théodorou, V., Majoral, J.P., Caminade, A.M., Prandi, J., Nigou, J. & Puzo, G. (2013) Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment. Proc Natl Acad Sci USA, 110(22), 8795-800.

Liu, C.F., Tonini, L., Malaga, W., Beau, M., Stella, A., Bouyssié, D., Jackson, M., Nigou, J., Puzo, G., Guilhot, C., Burlet-Schiltz, O. & Rivière, M. (2013) Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci USA, 110(16), 6560-5.