St George's, University of London, UK
Buruli ulcer disease, vaccines against Buruli ulcer and TB development, animal models, Clinical infectious diseases and immunity
Dr Boakye-Appiah’s research focuses on the development of vaccines against Buruli ulcer disease and Tuberculosis. He is currently trying various candidates and has succeeded in developing a mycolactone based vaccine candidate against Buruli ulcer disease. This vaccine demonstrates good prospects in mouse-models, providing full protection in immunized mice.
He has also recently won a VALIDATE Network Pump-Priming grant/funding to carry out animal trials with his novel Mycobacterium-based vaccine candidate against Tuberculosis.
Dr Boakye-Appiah is a medical doctor with interest in infectious diseases and vaccinology. Having worked in Ghana and in Liberia as a clinician and for the WHO in consulting capacity, he possesses a broad spectrum of skills ranging from clinic practice to lab based research and animal experimentation in the fields of infectious diseases and immunovaccinology.
JK Boakye-Appiah et al. High prevalence of multidrug-resistant tuberculosis among patients with rifampicin resistance using gene Xpert mycobacterium tuberculosis/rifampicin in ghana. Int. J. Mycobacteriol. (2016), http://dx.doi.org/10.1016/j.ijmyco.2016.02.004
Alicke M, Boakye-Appiah JK, Abdul-Jalil I, Henze A, van der Giet M, Schulze MB, et al. (2017) Adolescent health in rural Ghana: A cross-sectional study on the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors. PLoS ONE 12(7): e0180436. https://doi.org/10.1371/journal.pone.0180436
Bedu-Addo G, Alicke M, Boakye-Appiah JK, Abdul-Jalil I, van der Giet M, Schulze MB, Mockenhaupt FP, Danquah. In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study. J Infect. 2017 Nov; 75(5):455-463. doi: 10.1016/j.jinf.2017.08.010.
Loglo, A. D. et al (2018). IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection. PeerJ, 6, e5294. http://doi.org/10.7717/peerj.5294
Frimpong M, Agbavor B, Duah MS, Loglo A, Sarpong FN, Boakye-Appiah J, et al. (2019) Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load. PLoS Negl Trop Dis 13(8): e0007689. https://doi.org/10.1371/journal.pntd.0007689