Laura Matarazzo

Laura Matarazzo

Associated Professor

Faculdade de Medicina – Universidade Católica Portuguesa,  Portugal

Tel: +351 218724310






Network Associate


Research keywords:

Tuberculosis, mRNA vaccine



After a PhD at Institut Pasteur de Lille – France, and a postdoc at Trinity college Dublin, in the fields of respiratory infections, mucosal immunity, inflammation and immunomodulation-based anti-infectious therapies, I joined the Católica Medical School in Portugal in 2022 to lead a research project aimed at developing an mRNA vaccine platform against Tuberculosis. 

To this end, we are designing an mRNA vaccine based on relevant antigenic peptides identified by immunopeptidomics, and formulated with a newly patented technology of lipid nanoemulsions, designed for efficient delivery of mRNA. With this project, we want to impact the field of vaccine research, not only through the opportunity to develop a new vaccine candidate against tuberculosis, but also by providing an effective vaccine platform, which can be adapted to develop vaccines against other infectious diseases.


Key Publications:

  • MATARAZZO L, CASILAG F, PORTE R, WALLET F, CAYET D, FAVEEUW C, CARNOY C, SIRARD J-C. Therapeutic synergy between antibiotics and pulmonary Toll-like receptor 5 stimulation in antibiotic-sensitive or -resistant pneumonia. Frontiers in Immunology, 2019, doi: 10.3389/fimmu.2019.00723 
  • LIU X*, KIMMEY J*, MATARAZZO L*, DE BAKKER V, VAN MAELE L, SIRARD J-C, NIZET V, VEENING J-W. Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq. Cell Host & Microbe, 2020, doi: 10.1016/j.chom.2020.10.001
  • CASILAG F, MATARAZZO L, FRANCK S, FIGEACM, MICHELET R, KLOFT C, CARNOY C and SIRARD J-C. The Biosynthetic Monophosphoryl Lipid A Enhances theTherapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia. ACS - Infect Dis. 2021 Aug 13;7(8):2164-2175. doi: 10.1021/acsinfecdis.1c00176. Epub 2021 Jul 14. PMID: 34260199 
  • MATARAZZO L, HERNANDEZ SANTANA YE, WALSH PT, FALLON PG. The IL-1 cytokine family as custodians of barrier immunity. Cytokine 2022 Apr - 21;154:155890. doi: 10.1016/j.cyto.2022.155890. Epub ahead of print. PMID: 35462264.