Professor, Team Leader (TB immunology & vaccinology)
Animal and Plant Health Agency (APHA) / Aberystwyth University, UK
Tel: +44 (0)1932 341 111 (switchboard)
Network Investigator, Network Management Board member 2017-2018
Bovine TB, animal models, vaccines, DIVA diagnostics, correlates of protection
My group has been engaged in studying the immune responses in cattle after Mycobacterium bovis infection (BTB) or vaccination. In particular we are applying this knowledge to the development of improved cattle vaccines and immunodiagnostic reagents including reagents that are compatible with vaccination (DIVA). We are particularly interested in defining host markers that correlate either with disease severity or with vaccine efficacy. We apply both hypothesis and data-driven approaches including RNASeq based host transcriptome analysis to achieving these goals.
Metcalfe, H. J. et al. Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A. Vaccine 34, 4520-4525, (2016).
Steinbach, S., Vordermeier, H. M. & Jones, G. J. CD4+ and gammadelta T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle. Scientific reports 6, 29990, (2016).
Blunt, L. et al. Phenotypic characterization of bovine memory cells responding to mycobacteria in IFNgamma enzyme linked immunospot assays. Vaccine, (2015).
Dean, G. et al. Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines. Vaccine 32, 1304-1310 (2014).
Bhuju, S. et al. Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis. PLoS pathogens 8, e1003077 (2012).