Armauer Hansen Research Institute, Ethiopia
Cutaneous leishmaniasis, innate immune response
Dr Menberework Chanyalew, Negatue, PhD, studied biology (BSC) and Parasitology (MSC) at Addis Ababa University, Ethiopia. Her MSC project entitled “Leishmania aethiopica in Cercopithicus aethiops: Experimental infection and immune profile”.. She has been working as a researcher at Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia since 2004. She also worked as a lecturer at Dilla and Addis Ababa University, Ethiopia for more than 10 years. She conducted her doctoral project on innate immunity in cutaneous leishmaniasis in Professor Tamas laskay group in University of Lübeck, Germany and AHRI, Addis Ababa, Ethiopia. After completing PhD, She works as postdoctoral research fellow under the mentorship of Dr. Rawleigh Howe where she studies innate and adaptive immune response in Podoconiosis at AHRI. In addition, she also supervised postgraduate students who work on cutaneous leishmaniasis. Dr. Menberework Chanyalew is an assistant professor at the Bahir Dar University. Upon completion of her post-doctoral study, Menberework plans to peruse her career as an independent researcher in the field of immunology of cutaneous leishmaniasis and contribute to the development of new vaccine and therapies. She is looking toward to get collaborator to work together in the field of leishmaniasis.
- Chanyalew M, Abebe M, Endale B, Girma S, Tasew G, van Zandbergen G, Ritter U, Gadisa E, Aseffa A, Laskay T. (2021). Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica. Cytokine. 2021 Sep;145:155289. doi: 10.1016/j.cyto.2020.155289.
- Crauwels P, Bank E, Walber B, Wenzel UA, Agerberth B, Chanyalew M, Abebe M, König R, Ritter U, Reiling N, van Zandbergen G (2019). Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages. Front Immunol. 2019 Nov 22;10:2697.
- Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Jantsch J, Schatz V, Brown GD, Ritter U. (2018). Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development. Front Immunol. 2018 Feb 26;9:263. doi: 10.3389/fimmu.2018.00263
- Chanyalew M, Abebe M, Endale B, Girma S, Tasew G, Bobosha K, Zewide M, Howe R, van Zandbergen G, Ritter U, Gadisa E, Aseffa A, Laskay T. Enhanced activation of blood neutrophils and monocytes in patients with Ethiopian localized cutaneous leishmaniasis in response to Leishmania aethiopica Neutrophil activation in Ethiopian cutaneous leishmaniasis. Acta Trop. 2021 May 21;220:105967. doi: 10.1016/j.actatropica.2021.105967. [Epub ahead of print] PubMed PMID: 34029532.
- Tasew G, Gadisa E, Abera A, Chanyalew M, Abebe M, Howe R, Ritter U, Aseffa A, Laskay T. Whole blood-based in vitro culture reveals diminished secretion of pro-inflammatory cytokines and chemokines in visceral leishmaniasis. Cytokine. 2020 Aug 19;:155246. doi: 10.1016/j.cyto.2020.155246. [Epub ahead of print] PubMed PMID: 32828639.
- Gadisa, E., G. Tasew, A. Abera, W. Gelaye, M. Chanyalew, M. Abebe, T. Laskay and A. Aseffa (2017). "Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis." Cytokine 91: 6-9.
- Chanyalew M, Aseffa A, Harboe M, Olobo JO, Hailu A. (2009) Experimental infections with Leishmania aethiopica and immune response analysis of Cercopithecus aethiops. Ethiop. J. Health Biomed. Sci.2(1)
- Chanyalew M, Hailu A. Infection site dependent progression of cutaneous lesions in African green monkeys (cercopithecus aethiops) experimentally infected with leishmania aethiopica promastigotes. SINET: Ethiop. J. Sci. 2013:36(1):45-48.
- Negash M, Chanyalew M, T Gebresilase T, Sintayehu B, Anteye T, Aseffa A, Newport MJ. Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability. Trans R Soc Trop Med Hyg. 2021 Feb 11;. doi: 10.1093/trstmh/trab003. [Epub ahead of print] PubMed PMID: 33570141
- Ashenafi S, Muvva JR, Mily A, Snäll J, Zewdie M, Chanyalew M, Rehn A, Rahman S, Aseffa G, Bekele A, Aderaye G, Lema B, Svensson M, Brighenti S. Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV-Co-Infected Patients. Am J Pathol. 2022 Apr;192(4):653-670. doi: 10.1016/j.ajpath.2021.12.013. Epub 2022 Jan 31. PubMed PMID: 35092727; PubMed Central PMCID: PMC9302207.