VALIDATE Bioinformatician/Computational Biologist
University of Oxford, UK
Network Management Team Member, Network Associate
I recently joined the VALIDATE team as a computational biologist. Prior to this, I worked as postdoctoral scientist at the Ludwig Cancer Research on rare cancer called adrenocortical carcinoma (ACC). I analysed clinical, genotype and gene expression data derived from paediatric and adult patients. I identified a clinically relevant pathway linked to ACC progression that will help in ACC management and treatment. I also optimised a cellular model through the differentiation of induced Pluripotent Stem Cells to adrenal-like cells to study ACC in collaboration with the Stem cell institute, University of Oxford. I did my first postdoctoral post and DPhil at the Sir William Dunn School of Pathology, University of Oxford. I used different approaches (experimental models, organoid culture, cell lines, and RNA-seq) to study the effect of mutations in Smad4 and Igf2r on intestinal adenoma. I also worked on IGF2-TRAP that may be used for therapeutic targeting of IGF2 overexpression in cancer through functional evaluation of this protein on a hypoglycaemic experimental model.
I hold an undergraduate degree and a MSc degree in Medical Laboratory Sciences from Al-Quds University in Jerusalem. My research, in Haematology, focused on the correlation between Protease activated receptor 1 (Par1) polymorphism and recurrent abortion in Palestine.
My role at VALIDATE is to ensure that we maximise the output and lessons learned from the immunology and vaccine related data across the VALIDATE Network to advance vaccine research and development for our focus pathogens.
Available at PubMed
New paper available: A common polymorphism in the retinoic acid pathway modiﬁes adrenocortical carcinoma age-dependent incidence in British Journal of Cancer