Monika Looney

Monika Looney

Postdoctoral Research Fellow

South African Tuberculosis Vaccine Initiative (SATVI), University of Cape Town (UCT), South Africa

Email: monika.looney@uct.ac.za

 

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords:

TB, TB Vaccines, Single Cell RNA Sequencing, Immunology

 

Biography:

Dr. Looney is deeply passionate about ending TB. She received her PhD (2021) in Pathobiology from the Johns Hopkins School of Medicine, Department of Pathology. She conducted her thesis work on the dysregulation of small RNAs and methylation in human macrophages during infection with Mycobacterium tuberculosis in the lab of Professor Petros Karakousis, Center for Tuberculosis Research. During her graduate studies, she also received a Certificate in Global Health from the Johns Hopkins Bloomberg School of Public Health (2020).

Dr. Looney is currently completing her Postdoctoral Research Fellowship in single cell immunology at the South African Tuberculosis Vaccine Initiative (SATVI), University of Cape Town (UCT). Her research focuses on understanding human immunological responses to the antigens included in the novel TITAN mRNA TB vaccine and on using single cell RNA sequencing and immunophenotyping to identify immune correlates of protection elicited by the M72:AS01E TB vaccine candidate.

 

Related Websites:

PubMed

LinkedIn

SATVI

 

Key Publications:

  • Looney et al. (2023). Conference report: WHO meeting summary on mRNA-based tuberculosis vaccine development. Vaccine. doi: 10.1016/j.vaccine.2023.10.026
  • Looney et al. (2021). Mycobacterium tuberculosis infection drives mitochondria-biased dysregulation of host transfer RNA-derived fragments. J Infect Dis. doi: 10.1093/infdis/jiaa596
  • Looney et al. (2021). Key macrophage responses to infection with Mycobacterium tuberculosis are co-regulated by microRNAs and DNA methylation. Front Immunol. doi: 10.3389/fimmu.2021.685237