Nasrin Masoudzadeh
Researcher Pasteur Institute of Iran, Iran Email: nasrin.masoudzadeh@gmail.com
VALIDATE Role: Network Associate
Research Keywords: Cutaneous Leishmaniasis, Transcriptomics, Non-Coding RNAs, Checkpoints, Extracellular Vesicles, Vaccine
Biography: I am currently employed as a researcher at the Pasteur Institute of Iran (IPI). I have completed my Ph.D. in Molecular Medicine from IPI. In my previous research, I focused on the interaction between host and pathogen in patients infected with Leishmania (L.) tropica and L. major. We utilized high-throughput methods such as RNA sequencing, proximity extension assay, and dual-color reverse transcriptase multiplex ligation-dependent probe amplification (dcRT-MLPA) to study transcriptome and proteomics changes, biological processes, and key immunological pathways linked to localized immune response. Currently, my research interest lies in the presence and function of extracellular vesicles (EVs) in patients with cutaneous leishmaniasis (CL). I am investigating the composition of EVs, such as long non-coding RNA, in skin lesions of CL patients to identify possible targets for innovative therapeutic techniques, such as vaccination and drug candidates. Additionally, I am interested in researching immunological checkpoints in acute and chronic CL patients in order to create a logical plan for treatment based on checkpoint blocking and immunotherapy.
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