Prince of Songkla University, Thailand
TB, animal models, human studies, T cells
I’m currently a lecturer at Department of Medical Science, Faculty of Medicine, Prince of Songkla University. I did my PhD at the Jenner institute, University of Oxford on pre-clinical TB vaccine development. I hypothesize that immune responses to TB and vaccine efficacy differ between different populations, and are influenced by co-morbidities, coinfections with other pathogens and immunosuppressive conditions. In order to make a TB vaccine that protects in a particular population, immunological data from the target population is crucial. The proposed project will help to establish a clear understanding of immune responses against M.tb and identify immune recognition of M.tb antigens in this population. This research project will be conducted at Songklanagarind hospital to establish a cohort for this and future TB vaccine research.
Profile page at PSU
Pinpathomrat N, Stylianou E, Bull NC, Pasricha J, Harrington-Kandt R, McShane H. Evaluation of the immunogenicity of a promising vaccine regimen to identify immune correlates of protection. Vaccines (In progress).
Bettencourt P, Müller J, Nicastri A, Cantillon D, Madhavan M, Charles PD, Fotso CB, Wittenberg R, Bull N, Pinpathomrat N, Waddell SJ. Identification of antigens presented by MHC for vaccines against tuberculosis. npj Vaccines. 2020 Jan 3;5(1):1-4.
Bull NC, Stylianou E, Kaveh DA, Pinpathomrat N, Pasricha J, Harrington-Kandt R, Garcia-Pelayo MC, Hogarth PJ, McShane H. Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells. Mucosal immunology. 2018 Nov 16:1.
Stylianou E, Harrington-Kandt R, Beglov J, Bull N, Pinpathomrat N, Swarbrick GM, Lewinsohn DA, Lewinsohn DM, McShane H. Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate TB Subunit Vaccine. Infection and immunity. 2018 Apr 16:IA1-00014.
Harrington-Kandt R, Stylianou E, Eddowes LA, Lim PJ, Stockdale L, Pinpathomrat N, Bull N, Pasricha J, Ulaszewska M, Beglov Y, Vaulont S. Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M. tb infection model. PloS one. 2018 Jan 11;13(1):e0191038.