Nick de Vrij

nick de vrij

PhD Researcher

Institute of Tropical Medicine Antwerp, Belgium

Tel: +32456319042





Network Affiliate


Research Keywords: 

Leishmaniasis, T-Cell Immunity, TCR Repertoire, Epitope Mapping, Vaccinology



I am a PhD fellow at the Clinical Immunology unit of the Institute of Tropical Medicine in Antwerp and the Adrem Data Lab of the UAntwerp. Here, I focus on the T cell-driven immunity observed in leishmaniasis, and the entire process of T cell antigen presentation and recognition. By coupling high-throughput and high-resolution wet lab techniques with bioinformatics, I generate insights on pMHC-TCR interactions in leishmaniasis. During my PhD, I have gained ample experience in single-cell RNA and T cell receptor sequencing data analysis, and mass spectrometry-based immunopeptidomics. Moreover, I set up a Human Leukocyte Antigen sequencing pipeline, using Oxford Nanopore Technologies sequencers. In the context of capacity building, I implemented this pipeline at the University of Gondar in Ethiopia, and trained several local researchers to perform this routinely.


Related Websites: 

Linkedin Profile

University of Antwerp Profile

TG Portal Profile


Key Publications:

HLA-DRB1 Alleles Associated with Lower Leishmaniasis Susceptibility Share Common Amino Acid Polymorphisms and Epitope Binding Repertoires, de Vrij, N.; Meysman, P.; Gielis, S.; Adriaensen, W.; Laukens, K.; Cuypers, B, Vaccines 2021, 9, 270.