Nyarie Sithole
Postdoctoral Scholar University of California San Francisco (UCSF), United States of America (USA); University of Cambridge, United Kingdom (UK) Email: nyaradzai.sithole@ucsf.edu
VALIDATE Role: Network Associate
Research Keywords: TB, Animal Models, Mechanisms of Antibody Function Against Mtb.
Biography: I am an infectious diseases physician-scientist and currently a Wellcome Trust Career Development Fellow with joint appointments at UCSF and the University of Cambridge. My main research interest is on the role of antibody-mediated protection against tuberculosis. My career track started in Zimbabwe where I went to medical school, and then the UK, where I started my research career. My PhD was to understand how HIV-1 hijacks closely related human cellular DEAD box helicases, DDX5 and DDX17 to enhance viral transcription and splicing respectively (Sithole N, 2020 and Sithole N, 2018). With the onset of the COVID-19 pandemic, I was the first to establish a Long COVID clinic in May 2020 at Addenbrooke’s hospital in Cambridge and the clinic has expanded to be a hub for multi-disciplinary team management of Long COVID patients and productive collaborative research projects (Krishna B, 2022, 2023). As a Wellcome Trust Fellow, my interest has moved to the role of humoral immunity in tuberculosis – the world’s deadliest infectious disease, and one for which we still don’t have an effective vaccine that prevents or interrupts transmission. I have successfully been funded at every stage of my academic career and have a strong interest in mentorship and training. I am currently based in the lab of Dr. Babak Javid, member ASCI at UCSF, where I will leverage single-cell and spatial sequencing technologies to investigate the mechanisms by which TB-specific antibodies mediate protection, with the hope of using the knowledge gained to rationally improve preventative and therapeutic TB vaccine design.
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