Phil Hogarth

Phil Hogarth

Senior Immunologist

Animal & Plant Health Agency (APHA), UK

Tel: +44 (0)208 4152087

Email: Phil.Hogarth@apha.gov.uk

 

 

 

VALIDATE Role:

Network Investigator

 

Research Keywords: 

TB, bovine TB,  animal models, vaccine, mucosal Immunology, tissue resident memory, correlates of protection, flow cytometry

 

Biography:

Working in TB vaccine field for > 16 years, I am PI of a group studying mucosal immunology of TB, the immune response to vaccination and infection to understand: i) how vaccines generate T cell memory; and ii) how this affords protective immunity.  Major current interests include: the persistence of BCG vaccine & its role in protective immunity and the development and function of tissue-resident T cells in the lung induced by mucosal vaccination.

The overarching strategy of my work is: 'Understanding BCG protection for rational design of novel TB vaccines'.

Using a murine model of M. bovis infection, we use techniques such as: prime-boost & mucosal vaccination, 11+ colour flow, and T cell phenotyping to study protective CD4 T cells. We work using a One Health approach.

Previous interests include the role of IL-4/IL-5 in immunity to helminth parasites & fundamental T cell development in the gut.

 

Related Websites: 

Profile page on ResearchGate

 

Key Publications:

Kaveh, D.A., Carmen Garcia-Pelayo, M., Webb, P.R., Wooff, E.E., Bachy, V.S. & Hogarth, P.J. (2016)  Parenteral Adenoviral Boost Enhances BCG Induced Protection, but not Long Term Survival in a Murine Model of Bovine TB. Vaccine. 34:4003-11.doi:10.1016/j.vaccine.2016.06.032

Carmen Garcia-Pelayo, M., Kaveh, D.A., Sibley, L., Webb, P.R., Bachy, V.S., Cutting, S.M. & Hogarth, P.J. (2016) Boosting BCG with inert spores improves protective immunity in a murine model of bovine tuberculosis. Tuberculosis. 98:97-103.. DOI: 10.1016/j.tube.2016.03.004

Kaveh, D.A., Garcia-Pelayo, M. & Hogarth, P.J. (2014) Persistent BCG Bacilli Perpetuate CD4 T Effector Memory and Optimal Protection against Tuberculosis. Vaccine. 32:6911-6918. DOI: 10.1016/j.vaccine.2014.10.041

Kaveh, D.A., Whelan, A.O. & Hogarth, P.J. (2012) The duration of antigen-stimulation significantly alters the diversity of multifunctional CD4 T cells measured by intracellular cytokine staining. PLoS One. 7:e38926. DOI: 10.1371/journal.pone.0038926.

Arandhay-Cortes, E., Hogarth, P.J., &, Kaveh, D.K. Whelan, A.O., Lalvani, A. & Vordermeier, H.M. (2012). Transcriptional profiling of disease progression in bovine tuberculosis and the identification of potential diagnostic biomarkers PLoS One. 7: e30626. DOI: 10.1371/journal.pone.0030626

Whelan, A.O., Villarreal-Ramos, B., Vordermeier, H.M. & Hogarth P.J. (2011) Development of an antibody to bovine IL-2 & Multiparametric Flow Cytometry reveals multifunctional TEM cells in cattle naturally infected with bovine tuberculosis. PLoS One. 6: e29194. DOI: 10.1371/journal.pone.0029194

Arandhay Cortes, E., Kaveh, D., Nunez-Garcia., Hogarth, P.J. & Vordermeier, H.M. (2010). Mycobacterium bovis-BCG vaccination induces specific pulmonary transcriptome biosignatures in mice. PLoS One. 5: e11319. DOI: 10.1371/journal.pone.0011319

Logan, K.E., Gavier-Widen, D., Hewinson, R.G., & Hogarth, P.J.  (2008). Development of a Mycobacterium bovis intranasal challenge model in mice. Tuberculosis. 88: 37-43.

Hogarth P.J., Hewinson R.G & Vordermeier H.M. (2006) Development of vaccines against bovine tuberculosis. Journal of Pharmacy and Pharmacology. 58: 749-757.

Logan K.E., Chambers, M.A, Hewinson, R.G. & Hogarth, P.J. (2005). Frequency of IFN-γ producing cells correlates with antigen-independent enhancement of bacille Calmette-Guérin induced protection against Mycobacterium bovis. Vaccine. 23: 5526-5532.

Page, S.T., Bogatzki, L.Y., Hammerman, J.A., Sweenie, C.H., Hogarth, P.J., Malissen, M., Perlmutter, R.M. & Pullen, A.M. (1998). Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage. Proceedings of the National Academy of Sciences of the USA. 95 : 9459-9464.

Hogarth, P.J., Taylor, M.J. & Bianco A.E. (1998). IL-5 dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis. Journal of Immunology. 160: 5436-5440

Folkard, S.G., Hogarth, P.J., Taylor, M.J. & Bianco, A.E. (1996). Eosinophils are the major effector cells of immunity to microfilariae in a mouse model of onchocerciasis. Parasitology. 112: 323-329.